NDN and NUCB2

Number of citations of the paper that reports this interaction (PubMedID 10915798)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NDN	NUCB2
Description		necdin, MAGE family member	nucleobindin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Protein-containing Complex Cell Projection Perikaryon	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Gamma-tubulin Binding Promoter-specific Chromatin Binding	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Respiratory System Process Regulation Of DNA-templated Transcription Axonogenesis Axonal Fasciculation Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Neuron Development Axon Extension Multicellular Organismal-level Homeostasis Genomic Imprinting	Small GTPase-mediated Signal Transduction
Pathways		Interleukin-4 and Interleukin-13 signaling
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Body size at age 10 ( 32376654) Depressive symptoms (SSRI exposure interaction) ( 25649181) HDL cholesterol levels ( 32203549) Parkinson's disease (age of onset) ( 33884653) Plasma anti-thyroid peroxidase levels ( 29678681) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Body mass index ( 26426971) Height ( 20881960) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28739976) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		47 interacting genes: APBB1IP ARSL BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EEF1AKMT1 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 IRS4 LAX1 LPXN MIER2 MKRN2 MYG1 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PALS2 PJA1 PPARGC1A PPFIA1 SERTAD3 SIRT1 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B	12 interacting genes: ARL13B ASPH FFAR2 GADD45A GNAI3 GNAS NDN NR1I2 SLC7A1 SMARCD1 STAR XPO1
Entrez ID		4692	4925
HPRD ID		03667	09726
Ensembl ID		ENSG00000182636	ENSG00000070081
Uniprot IDs		Q99608 X5D982	P80303 Q2L696
PDB IDs
Enriched GO Terms of Interacting Partners?		Cis-regulatory Region Sequence-specific DNA Binding Axo-dendritic Transport Circadian Rhythm Transport Along Microtubule Cellular Response To Hypoxia Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Neuron Apoptotic Process Cytoskeleton-dependent Intracellular Transport Axon Cytoplasm Microtubule-based Transport Axonal Transport Circadian Regulation Of Gene Expression Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Cytoplasm Cellular Response To Decreased Oxygen Levels DNA-binding Transcription Activator Activity Promoter-specific Chromatin Binding Embryonic Placenta Development Cellular Homeostasis Regulation Of MiRNA Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Rhythmic Process Cellular Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Chemical Homeostasis Organelle Transport Along Microtubule Intracellular Glucose Homeostasis Regulation Of Fibroblast Proliferation Positive Regulation Of Biosynthetic Process Stress-induced Premature Senescence Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex MRNA Metabolic Process PML Body Anterograde Axonal Transport Nuclear Receptor Binding Connective Tissue Replacement Microtubule-based Process Intracellular Oxygen Homeostasis Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Protein Domain Specific Binding	Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Regulation Of Protein Transport Heterotrimeric G-protein Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Lipid Cellular Response To Fatty Acid Regulation Of Establishment Of Protein Localization Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Regulation Of Multicellular Organismal Process Peptidyl-aspartic Acid 3-dioxygenase Activity Promoter-specific Chromatin Binding Mu-type Opioid Receptor Binding Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Response To Fatty Acid Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Lysine Transport L-histidine Import Across Plasma Membrane Cellular Response To Triglyceride
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