NDN and FAM131C

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid, two hybrid)

		NDN	FAM131C
Description		necdin, MAGE family member	family with sequence similarity 131 member C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Protein-containing Complex Cell Projection Perikaryon
	Molecular Function	DNA Binding Protein Binding Gamma-tubulin Binding Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Respiratory System Process Regulation Of DNA-templated Transcription Axonogenesis Axonal Fasciculation Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Neuron Development Axon Extension Multicellular Organismal-level Homeostasis Genomic Imprinting
Pathways		Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Body size at age 10 ( 32376654) Depressive symptoms (SSRI exposure interaction) ( 25649181) HDL cholesterol levels ( 32203549) Parkinson's disease (age of onset) ( 33884653) Plasma anti-thyroid peroxidase levels ( 29678681) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Cognitive performance ( 19734545) Normal facial asymmetry (angle of surface orientation score) ( 30631343)
Interacting Genes		47 interacting genes: APBB1IP ARSL BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EEF1AKMT1 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 IRS4 LAX1 LPXN MIER2 MKRN2 MYG1 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PALS2 PJA1 PPARGC1A PPFIA1 SERTAD3 SIRT1 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B	12 interacting genes: APP CRYAA DNAJA3 EWSR1 GRN HPCAL4 LMO3 MAD1L1 NDN SFI1 VSNL1 WWP2
Entrez ID		4692	348487
HPRD ID		03667	08779
Ensembl ID		ENSG00000182636	ENSG00000185519
Uniprot IDs		Q99608 X5D982	Q96AQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cis-regulatory Region Sequence-specific DNA Binding Axo-dendritic Transport Circadian Rhythm Transport Along Microtubule Cellular Response To Hypoxia Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Neuron Apoptotic Process Cytoskeleton-dependent Intracellular Transport Axon Cytoplasm Microtubule-based Transport Axonal Transport Circadian Regulation Of Gene Expression Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Cytoplasm Cellular Response To Decreased Oxygen Levels DNA-binding Transcription Activator Activity Promoter-specific Chromatin Binding Embryonic Placenta Development Cellular Homeostasis Regulation Of MiRNA Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Rhythmic Process Cellular Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Chemical Homeostasis Organelle Transport Along Microtubule Intracellular Glucose Homeostasis Regulation Of Fibroblast Proliferation Positive Regulation Of Biosynthetic Process Stress-induced Premature Senescence Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex MRNA Metabolic Process PML Body Anterograde Axonal Transport Nuclear Receptor Binding Connective Tissue Replacement Microtubule-based Process Intracellular Oxygen Homeostasis Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Protein Domain Specific Binding	Astrocyte Activation Involved In Immune Response Response To Heat Astrocyte Activation Central Nervous System Development Response To Temperature Stimulus Negative Regulation Of Signaling Microglial Cell Activation Negative Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Neuron Recognition Synapse Organization Protein Stabilization Positive Regulation Of Aspartic-type Peptidase Activity MAD1 Complex Regulation Of Cell Activation Macrophage Activation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Protein Stability Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Folding Positive Regulation Of Trophectodermal Cell Proliferation Deactivation Of Mitotic Spindle Assembly Checkpoint Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Mitotic Cell Cycle Response To Norepinephrine
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