NRDC and FGF11

Data Source: HiPPIP (Novel)

		NRDC	FGF11
Name		nardilysin convertase	fibroblast growth factor 11
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Cell Surface Dendrite Cell Projection	Nucleus Cytoplasm
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding Epidermal Growth Factor Binding Endopeptidase Activator Activity	Protein Binding Growth Factor Activity Sodium Channel Regulator Activity
	Biological Process	Proteolysis Positive Regulation Of Myelination Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Axonogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Signal Transduction Cell-cell Signaling Nervous System Development Neurogenesis
Pathways		None	Phase 0 - rapid depolarisation
GWAS		Appendicular lean mass ( 33097823 )	Brain morphology (MOSTest) ( 32665545 ) Refractive error ( 32231278 )
Interacting Genes		6 interacting genes: CALCA H3C14 HBEGF NLGN3 PDYN POMC	4 interacting genes: HMBOX1 RPL22 STAC3 THAP1
Entrez ID		4898	2256
HPRD ID		04036	03304
Ensembl ID		ENSG00000078618	ENSG00000161958
Uniprot IDs		G3V1R5 O43847 Q6UUU9	A0A7U3JVZ5 B7Z1C3 Q92914
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cell-cell Signaling Cell Communication Signaling Neuronal Dense Core Vesicle Hippocampal Mossy Fiber To CA3 Synapse Regulation Of System Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Oxytocin Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Amylin Receptor 1 Signaling Pathway Calcitonin Receptor Binding Signaling Receptor Binding Endocytosis Amylin Receptor 2 Signaling Pathway Hormone Activity Insulin Receptor Complex Neuropeptide Signaling Pathway Opioid Receptor Binding Opioid Peptide Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Neutrophil Mediated Killing Of Fungus Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Response To Melanocyte-stimulating Hormone Asymmetric, Glutamatergic, Excitatory Synapse Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse	Identical Protein Binding Translation At Presynapse PML Body Telomere-telomerase Complex Assembly