NRD1 and HBEGF

Number of citations of the paper that reports this interaction (PMID 11432822)
26

Data Source:
HPRD (in vitro, in vivo)

		NRD1	HBEGF
Gene Name		nardilysin (N-arginine dibasic convertase)	heparin-binding EGF-like growth factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell Surface	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding Epidermal Growth Factor Binding	Epidermal Growth Factor Receptor Binding Growth Factor Activity Heparin Binding
	Biological Process	Proteolysis Neuromuscular Junction Development Cell Proliferation Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Muscle Organ Development Regulation Of Heart Contraction Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Wound Healing, Spreading Of Epidermal Cells Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Elastin Biosynthetic Process Positive Regulation Of Keratinocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Wound Healing
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling EGFR Transactivation by Gastrin PI3K/AKT activation Uptake and actions of bacterial toxins PI-3K cascade GRB2 events in ERBB2 signaling Gastrin-CREB signalling pathway via PKC and MAPK PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Uptake and function of diphtheria toxin
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CALCA HBEGF HIST2H3C PDYN POMC	11 interactors: BAG1 CD44 CD82 CD9 EGFR ERBB4 FBLN1 LTBP3 MMP7 NRD1 ZBTB16
Entrez ID		4898	1839
HPRD ID		04036	00526
Ensembl ID		ENSG00000078618	ENSG00000113070
Uniprot IDs		B1AKJ5 G3V1R5 O43847 Q6UUU9	Q99075
PDB IDs			1XDT
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Negative Regulation Of Elastin Biosynthetic Process Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Blood Pressure Regulation Of Corticosterone Secretion Positive Regulation Of Keratinocyte Migration G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Cell Surface Receptor Signaling Pathway Blood Circulation Negative Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Macrophage Differentiation Negative Regulation Of Bone Resorption Wound Healing, Spreading Of Epidermal Cells DNA Methylation On Cytosine Negative Regulation Of Glycoprotein Metabolic Process G-protein Coupled Receptor Internalization Negative Regulation Of Bone Remodeling Negative Regulation Of Neurological System Process Monocyte Chemotaxis Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Tissue Remodeling Chromatin Silencing At RDNA Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Endothelial Cell Proliferation Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Muscle Contraction Regulation Of Appetite Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Cytokine Production Response To Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Wound Healing Response To Growth Factor Activation Of Adenylate Cyclase Activity Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Interleukin-8 Production Sensory Perception Of Temperature Stimulus Positive Regulation Of Interleukin-1 Production Positive Regulation Of Vasodilation	Regulation Of Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Single Organism Reproductive Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Regulation Of Protein Metabolic Process Secretion Positive Regulation Of Metabolic Process Reproductive Process Anatomical Structure Morphogenesis Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Regulation Of Cell Death Developmental Process Cell Migration Cell Motility System Development Negative Regulation Of Apoptotic Process Regulation Of Chondrocyte Differentiation Negative Regulation Of Programmed Cell Death Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Mesenchymal Stem Cell Proliferation Transforming Growth Factor Beta Activation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Death Regulation Of Cellular Amino Acid Metabolic Process Organ Development Programmed Cell Death Regulation Of Peptidase Activity Embryonic Pattern Specification Regulation Of Cartilage Development Cell Death Death Regulation Of Protein Phosphorylation
Tagcloud ?		cerevisiae dcr1 deacetylase dicer eliminates h3k9me heterochromatin lacks lncrnas lys9 mark modifying ncrnas noncoding nurd ortholog pericentromeric pombe recruit recruiting repressive rnai saccharomyces schizosaccharomyces seb1 shrec snf2 transcribed unstable	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa
Tagcloud (Difference) ?		cerevisiae dcr1 deacetylase dicer eliminates h3k9me heterochromatin lacks lncrnas lys9 mark modifying ncrnas noncoding nurd ortholog pericentromeric pombe recruit recruiting repressive rnai saccharomyces schizosaccharomyces seb1 shrec snf2 transcribed unstable	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa
Tagcloud (Intersection) ?