NRD1 and CALCA

Number of citations of the paper that reports this interaction (PMID 12590613)
2

Data Source:
HPRD (in vitro)

		NRD1	CALCA
Gene Name		nardilysin (N-arginine dibasic convertase)	calcitonin-related polypeptide alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell Surface	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding Epidermal Growth Factor Binding	Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Protein Complex Binding Identical Protein Binding
	Biological Process	Proteolysis Neuromuscular Junction Development Cell Proliferation Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity	Endothelial Cell Proliferation Vasculature Development Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Rate G-protein Coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Embryo Implantation Aging Feeding Behavior Regulation Of Blood Pressure Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Ossification Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Negative Regulation Of Neurological System Process Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Negative Regulation Of Smooth Muscle Contraction Response To Pain Regulation Of Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cytosolic Calcium Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Amyloids Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors) Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CALCA HBEGF HIST2H3C PDYN POMC	7 interactors: BBS1 BBS4 CALCRL ECE1 NRD1 RAMP1 RAMP2
Entrez ID		4898	796
HPRD ID		04036	00238
Ensembl ID		ENSG00000078618	ENSG00000110680
Uniprot IDs		B1AKJ5 G3V1R5 O43847 Q6UUU9	P01258 P06881
PDB IDs			1LS7 2JXZ
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Negative Regulation Of Elastin Biosynthetic Process Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Blood Pressure Regulation Of Corticosterone Secretion Positive Regulation Of Keratinocyte Migration G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Cell Surface Receptor Signaling Pathway Blood Circulation Negative Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Macrophage Differentiation Negative Regulation Of Bone Resorption Wound Healing, Spreading Of Epidermal Cells DNA Methylation On Cytosine Negative Regulation Of Glycoprotein Metabolic Process G-protein Coupled Receptor Internalization Negative Regulation Of Bone Remodeling Negative Regulation Of Neurological System Process Monocyte Chemotaxis Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Tissue Remodeling Chromatin Silencing At RDNA Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Endothelial Cell Proliferation Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Muscle Contraction Regulation Of Appetite Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Cytokine Production Response To Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Wound Healing Response To Growth Factor Activation Of Adenylate Cyclase Activity Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Interleukin-8 Production Sensory Perception Of Temperature Stimulus Positive Regulation Of Interleukin-1 Production Positive Regulation Of Vasodilation	Receptor Internalization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Cardiovascular System Development Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Development Anatomical Structure Morphogenesis Protein Localization To Plasma Membrane Nonmotile Primary Cilium Assembly Regulation Of Blood Pressure Protein Transport Establishment Of Protein Localization CAMP Biosynthetic Process Plasma Membrane Organization Photoreceptor Cell Maintenance CAMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Protein Localization Blood Circulation Calcium Ion Transport Angiogenesis Cyclic Nucleotide Biosynthetic Process Receptor-mediated Endocytosis Protein Localization To Membrane Retina Homeostasis Blood Vessel Morphogenesis Endomembrane System Organization Cyclic Nucleotide Metabolic Process Positive Regulation Of Cellular Metabolic Process Calcitonin Catabolic Process Substance P Catabolic Process Endothelin Maturation Cellular Response To Sucrose Stimulus Cellular Protein Localization Blood Vessel Development Regulation Of Systemic Arterial Blood Pressure Vasculature Development Vesicle-mediated Transport Anatomical Structure Development Intracellular Transport Neuropeptide Catabolic Process Endocytosis Positive Regulation Of Cilium Assembly Sensory Processing Basement Membrane Assembly Developmental Process
Tagcloud ?		cerevisiae dcr1 deacetylase dicer eliminates h3k9me heterochromatin lacks lncrnas lys9 mark modifying ncrnas noncoding nurd ortholog pericentromeric pombe recruit recruiting repressive rnai saccharomyces schizosaccharomyces seb1 shrec snf2 transcribed unstable	11p 11p15 allelic anaplastic constitutional differentiated federation figo gynecology heterozygosity homozygosity hras1 informative ins leukocytes loh losses marks obstetrics ovarian p20 pej6 pem36 phins310 polymorphic pth sense spanning tumorigenicity
Tagcloud (Difference) ?		cerevisiae dcr1 deacetylase dicer eliminates h3k9me heterochromatin lacks lncrnas lys9 mark modifying ncrnas noncoding nurd ortholog pericentromeric pombe recruit recruiting repressive rnai saccharomyces schizosaccharomyces seb1 shrec snf2 transcribed unstable	11p 11p15 allelic anaplastic constitutional differentiated federation figo gynecology heterozygosity homozygosity hras1 informative ins leukocytes loh losses marks obstetrics ovarian p20 pej6 pem36 phins310 polymorphic pth sense spanning tumorigenicity
Tagcloud (Intersection) ?