NRDC and CALCA

Number of citations: 0 (PubMedID 12590613)
Data Source: HPRD (in vitro)

		NRDC	CALCA
Name		nardilysin convertase	calcitonin related polypeptide alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Cell Surface Dendrite Cell Projection	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding Epidermal Growth Factor Binding Endopeptidase Activator Activity	Signaling Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding Protein-containing Complex Binding Receptor Ligand Activity
	Biological Process	Proteolysis Positive Regulation Of Myelination Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Axonogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Response To Yeast Endothelial Cell Proliferation Vasculature Development Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Embryo Implantation Regulation Of Blood Pressure Negative Regulation Of Calcium Ion Transport Into Cytosol Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Vasodilation Endothelial Cell Migration Innate Immune Response Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Contraction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Tumor Necrosis Factor Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways		None	G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs		None	Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab
GWAS		Appendicular lean mass ( 33097823 )	Diverticular disease ( 30177863 ) Hip circumference adjusted for BMI ( 34021172 ) Vitamin D levels ( 25208829 )
Interacting Genes		6 interacting genes: CALCA H3C14 HBEGF NLGN3 PDYN POMC	8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2
Entrez ID		4898	796
HPRD ID		04036	00238
Ensembl ID		ENSG00000078618	ENSG00000110680
Uniprot IDs		G3V1R5 O43847 Q6UUU9	P01258 P06881
PDB IDs		Not available	2JXZ 6E3Y 7KNU 7TYH 7TYO 9AUC
GO Terms Enriched among Interactors		Cell-cell Signaling Cell Communication Signaling Neuronal Dense Core Vesicle Hippocampal Mossy Fiber To CA3 Synapse Regulation Of System Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Oxytocin Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Amylin Receptor 1 Signaling Pathway Calcitonin Receptor Binding Signaling Receptor Binding Endocytosis Amylin Receptor 2 Signaling Pathway Hormone Activity Insulin Receptor Complex Neuropeptide Signaling Pathway Opioid Receptor Binding Opioid Peptide Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Neutrophil Mediated Killing Of Fungus Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Response To Melanocyte-stimulating Hormone Asymmetric, Glutamatergic, Excitatory Synapse Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse	Calcitonin Family Receptor Signaling Pathway Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Amylin Receptor Signaling Pathway BBSome Receptor Internalization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Striatum Development Regulation Of Cilium Beat Frequency Retina Homeostasis Brain Morphogenesis Ventricular System Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Face Development Regulation Of Blood Pressure Receptor-mediated Endocytosis Protein Localization To Plasma Membrane Establishment Of Protein Localization Regulation Of Cilium Movement Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Photoreceptor Cell Maintenance Calcium Ion Transport Dendrite Development Heart Development Non-motile Cilium Assembly Regulation Of Microtubule-based Movement G Protein-coupled Receptor Signaling Pathway Ciliary Membrane Protein Localization To Membrane Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Coreceptor Activity Protein Localization To Cilium Endothelin Maturation Calcitonin Catabolic Process Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Binding Hippocampus Development Intracellular Protein Localization Sensory Perception Of Smell Cerebral Cortex Development Metalloendopeptidase Activity Endocytosis