NRD1 and PDYN

Number of citations of the paper that reports this interaction (PMID 12590613)
2

Data Source:
HPRD (in vitro)

		NRD1	PDYN
Gene Name		nardilysin (N-arginine dibasic convertase)	prodynorphin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell Surface	Extracellular Region Plasma Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding Epidermal Growth Factor Binding	Opioid Peptide Activity
	Biological Process	Proteolysis Neuromuscular Junction Development Cell Proliferation Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity	Neuropeptide Signaling Pathway Synaptic Transmission
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G-protein activation Class A/1 (Rhodopsin-like receptors) Opioid Signalling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Aortic root size ( 21223598) Immune response to smallpox vaccine (IL-6) ( 22542470)
Protein-Protein Interactions		5 interactors: CALCA HBEGF HIST2H3C PDYN POMC	2 interactors: APP NRD1
Entrez ID		4898	5173
HPRD ID		04036	08838
Ensembl ID		ENSG00000078618	ENSG00000101327
Uniprot IDs		B1AKJ5 G3V1R5 O43847 Q6UUU9	P01213
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Negative Regulation Of Elastin Biosynthetic Process Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Blood Pressure Regulation Of Corticosterone Secretion Positive Regulation Of Keratinocyte Migration G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Cell Surface Receptor Signaling Pathway Blood Circulation Negative Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Macrophage Differentiation Negative Regulation Of Bone Resorption Wound Healing, Spreading Of Epidermal Cells DNA Methylation On Cytosine Negative Regulation Of Glycoprotein Metabolic Process G-protein Coupled Receptor Internalization Negative Regulation Of Bone Remodeling Negative Regulation Of Neurological System Process Monocyte Chemotaxis Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Tissue Remodeling Chromatin Silencing At RDNA Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Endothelial Cell Proliferation Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Muscle Contraction Regulation Of Appetite Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Cytokine Production Response To Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Wound Healing Response To Growth Factor Activation Of Adenylate Cyclase Activity Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Interleukin-8 Production Sensory Perception Of Temperature Stimulus Positive Regulation Of Interleukin-1 Production Positive Regulation Of Vasodilation	Neuromuscular Junction Development Synapse Organization Synaptic Growth At Neuromuscular Junction Positive Regulation Of Proteolysis Collateral Sprouting In Absence Of Injury Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Regulation Of Proteolysis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Metabolic Process Mating Behavior Locomotion Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Movement Of Cell Or Subcellular Component Axon Cargo Transport Mating Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		cerevisiae dcr1 deacetylase dicer eliminates h3k9me heterochromatin lacks lncrnas lys9 mark modifying ncrnas noncoding nurd ortholog pericentromeric pombe recruit recruiting repressive rnai saccharomyces schizosaccharomyces seb1 shrec snf2 transcribed unstable	aceh3k9 ana ascending bdnf bni cessation dynorphin hdac horn hydroxamic hyperalgesia hypersensitivity immuoprecipation lastly lysine9 maladaptations morphine neurotrophic oih opioid opioids prodynorphin prolongation resolves saha seeks suberoylanilide trkb tropomyosin
Tagcloud (Difference) ?		cerevisiae dcr1 deacetylase dicer eliminates h3k9me heterochromatin lacks lncrnas lys9 mark modifying ncrnas noncoding nurd ortholog pericentromeric pombe recruit recruiting repressive rnai saccharomyces schizosaccharomyces seb1 shrec snf2 transcribed unstable	aceh3k9 ana ascending bdnf bni cessation dynorphin hdac horn hydroxamic hyperalgesia hypersensitivity immuoprecipation lastly lysine9 maladaptations morphine neurotrophic oih opioid opioids prodynorphin prolongation resolves saha seeks suberoylanilide trkb tropomyosin
Tagcloud (Intersection) ?