DRD3 and EEF1G

Number of citations of the paper that reports this interaction (PMID 14519448)
4

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DRD3	EEF1G
Gene Name		dopamine receptor D3	eukaryotic translation elongation factor 1 gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Cell Projection Apical Part Of Cell	Nucleus Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Protein Binding Drug Binding Protein Domain Specific Binding D1 Dopamine Receptor Binding Dopamine Binding	Translation Elongation Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Positive Regulation Of Cell Proliferation Visual Learning Regulation Of Dopamine Secretion Regulation Of Lipid Metabolic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Gastric Emptying Positive Regulation Of Renal Sodium Excretion Regulation Of Multicellular Organism Growth Response To Cocaine Dopamine Metabolic Process Response To Drug Response To Morphine Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Kinase B Signaling Prepulse Inhibition Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process
Pathways			Translation Eukaryotic Translation Elongation
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Sulpiride Remoxipride Pramipexole Haloperidol Lisuride Apomorphine Risperidone Dopamine Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Asenapine Amisulpride
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CLIC6 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX USP48	87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24
Entrez ID		1814	1937
HPRD ID		00540	11745
Ensembl ID		ENSG00000151577	ENSG00000254772
Uniprot IDs		E9PCM4	P26641 Q53YD7
PDB IDs			1PBU
Enriched GO Terms of Interacting Partners?		Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Platelet Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cytoskeleton Organization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Cell Activation Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Actin Filament Polymerization Cell-cell Signaling Blood Coagulation Hemostasis Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Polymerization Posttranscriptional Regulation Of Gene Expression Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Stability Phosphatidylinositol-mediated Signaling Regulation Of Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Projection Organization Positive Regulation Of Protein Complex Assembly Regulation Of Body Fluid Levels Translational Elongation Synaptic Transmission Wound Healing Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Signal Transduction Branching Involved In Labyrinthine Layer Morphogenesis	Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity
Tagcloud ?		admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero	4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Difference) ?		admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero	4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Intersection) ?