DRD3 and EEF1B2

Number of citations of the paper that reports this interaction (PMID 14519448)
4

Data Source:
HPRD (in vivo, in vitro)

		DRD3	EEF1B2
Gene Name		dopamine receptor D3	eukaryotic translation elongation factor 1 beta 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Cell Projection Apical Part Of Cell	Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Protein Binding Drug Binding Protein Domain Specific Binding D1 Dopamine Receptor Binding Dopamine Binding	Translation Elongation Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Positive Regulation Of Cell Proliferation Visual Learning Regulation Of Dopamine Secretion Regulation Of Lipid Metabolic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Gastric Emptying Positive Regulation Of Renal Sodium Excretion Regulation Of Multicellular Organism Growth Response To Cocaine Dopamine Metabolic Process Response To Drug Response To Morphine Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Kinase B Signaling Prepulse Inhibition Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior	Translation Translational Elongation Gene Expression Cellular Protein Metabolic Process
Pathways			Translation Eukaryotic Translation Elongation
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Sulpiride Remoxipride Pramipexole Haloperidol Lisuride Apomorphine Risperidone Dopamine Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Asenapine Amisulpride
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CLIC6 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX USP48	10 interactors: AARS APP CSNK2A1 CSNK2A2 DRD3 EEF1G HARS TIMP1 ULK2 VHL
Entrez ID		1814	1933
HPRD ID		00540	02804
Ensembl ID		ENSG00000151577	ENSG00000114942
Uniprot IDs		E9PCM4	P24534
PDB IDs			1B64
Enriched GO Terms of Interacting Partners?		Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Platelet Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cytoskeleton Organization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Cell Activation Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Actin Filament Polymerization Cell-cell Signaling Blood Coagulation Hemostasis Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Polymerization Posttranscriptional Regulation Of Gene Expression Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Stability Phosphatidylinositol-mediated Signaling Regulation Of Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Projection Organization Positive Regulation Of Protein Complex Assembly Regulation Of Body Fluid Levels Translational Elongation Synaptic Transmission Wound Healing Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Signal Transduction Branching Involved In Labyrinthine Layer Morphogenesis	Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Neuromuscular Process Response To External Stimulus Regulation Of Cell Cycle Process Cell Morphogenesis Cellular Protein Metabolic Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Cellular Metabolic Process Regulation Of Growth Regulation Of Mitotic Cell Cycle Phase Transition Neuron Projection Morphogenesis Regulation Of Cell Cycle Phase Transition Regulation Of Proteolysis Nervous System Development Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Cell Division Negative Regulation Of Endopeptidase Activity Cell Morphogenesis Involved In Differentiation Negative Regulation Of Peptidase Activity Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Neurogenesis Regulation Of Developmental Growth Negative Regulation Of Catalytic Activity Regulation Of Mitotic Metaphase/anaphase Transition Generation Of Neurons Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Cell Development Visual Learning Cell Part Morphogenesis Neurogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Visual Behavior Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Apoptotic Process Platelet Degranulation
Tagcloud ?		admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero	aberration aberrations amplicons amplifications cna cnas concordance concordant copy featured gains gistic grouped hnf4a instable microsatellite msi mss oncogenes petacc ptk6 q q23 reinforce smad4 suppressors unlinked wnk1 wwox
Tagcloud (Difference) ?		admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero	aberration aberrations amplicons amplifications cna cnas concordance concordant copy featured gains gistic grouped hnf4a instable microsatellite msi mss oncogenes petacc ptk6 q q23 reinforce smad4 suppressors unlinked wnk1 wwox
Tagcloud (Intersection) ?