DRD3 and GNAI1

Number of citations of the paper that reports this interaction (PMID 10978845)
13

Data Source:
HPRD (in vivo)

		DRD3	GNAI1
Gene Name		dopamine receptor D3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Cell Projection Apical Part Of Cell	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Extracellular Vesicular Exosome
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Protein Binding Drug Binding Protein Domain Specific Binding D1 Dopamine Receptor Binding Dopamine Binding	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Positive Regulation Of Cell Proliferation Visual Learning Regulation Of Dopamine Secretion Regulation Of Lipid Metabolic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Gastric Emptying Positive Regulation Of Renal Sodium Excretion Regulation Of Multicellular Organism Growth Response To Cocaine Dopamine Metabolic Process Response To Drug Response To Morphine Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Kinase B Signaling Prepulse Inhibition Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior	Cell Cycle G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Platelet Activation Response To Peptide Hormone Cell Division
Pathways			Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Sulpiride Remoxipride Pramipexole Haloperidol Lisuride Apomorphine Risperidone Dopamine Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Asenapine Amisulpride
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CLIC6 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX USP48	57 interactors: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		1814	2770
HPRD ID		00540	00756
Ensembl ID		ENSG00000151577	ENSG00000127955
Uniprot IDs		E9PCM4	P63096
PDB IDs			1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2PZ3 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q
Enriched GO Terms of Interacting Partners?		Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Platelet Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cytoskeleton Organization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Cell Activation Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Actin Filament Polymerization Cell-cell Signaling Blood Coagulation Hemostasis Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Polymerization Posttranscriptional Regulation Of Gene Expression Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Stability Phosphatidylinositol-mediated Signaling Regulation Of Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Projection Organization Positive Regulation Of Protein Complex Assembly Regulation Of Body Fluid Levels Translational Elongation Synaptic Transmission Wound Healing Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Signal Transduction Branching Involved In Labyrinthine Layer Morphogenesis	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Catalytic Activity Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of Signaling Positive Regulation Of Hydrolase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sphingosine-1-phosphate Signaling Pathway Regulation Of Cellular Process Chemical Homeostasis Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Positive Regulation Of GTPase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Synaptic Transmission Negative Regulation Of Signaling Behavior Cellular Metal Ion Homeostasis Neuropeptide Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Ion Homeostasis Cellular Ion Homeostasis Homeostatic Process Metal Ion Homeostasis Negative Regulation Of Signal Transduction Cellular Chemical Homeostasis Locomotory Behavior Response To Ammonium Ion Negative Regulation Of Ion Transport Response To Cocaine Regulation Of Cell Proliferation Neurological System Process
Tagcloud ?		admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero	alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero	alkenes azotic constructions gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?