FAM9B and SLPI

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		FAM9B	SLPI
Description		family with sequence similarity 9 member B	secretory leukocyte peptidase inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Cytoplasm	Extracellular Region Extracellular Space Golgi Apparatus Extracellular Matrix Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Peptidase Inhibitor Activity
	Biological Process	Spermatid Development Meiotic Cell Cycle	Immune System Process Immune Response Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Host-mediated Perturbation Of Symbiont Process
Pathways			Neutrophil degranulation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Androgen levels ( 22936694) Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 29403010) Hemoglobin ( 29403010) Male-pattern baldness ( 27182965 29146897) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)
Interacting Genes		140 interacting genes: ABT1 ACP6 ANKRD36B AP1M1 ASB6 ATF7 AURKAIP1 BAG6 BAIAP2L2 BARD1 BCL2A1 BET1 BLOC1S2 BRME1 BYSL C8orf33 CADPS CCDC106 CCDC116 CCDC198 CCDC70 CDC23 CDC37 CDC42EP4 CDCA7L CDSN CENPL CEP57L1 CEP95 CHRAC1 CLCN1 CMTM6 COL20A1 CSDE1 CWF19L2 DAPK2 DAXX DENND2D DGUOK DNAJC15 DNAJC4 EBNA1BP2 ECH1 EIF3G ELOA FAM161A FAM9A FASTKD3 FCHSD2 FERD3L FNDC11 GFOD1 GOPC GPX1 GRAMD4 GSTK1 HAPSTR1 HNRNPLL IBSP ISCU JAZF1 LBX1 LIN7A LINC02363 LMNA LNX1 LYRM2 MAB21L3 MFAP1 MOB1A MORF4L1 MORF4L2 MRPL10 MRPL28 MRPL9 MRRF MYG1 MYO15B NDE1 NDUFB10 NEBL NOL4 NOTO PAGE1 PAGE3 PHYH PIN4 POLL PPARA PPP1R18 PRPF3 PSMD14 PTRH1 RAB17 RAD51B RBM17 RBM23 RMND1 RNF8 RPL9 RSL24D1 RUBCN RUSC1 SDCBP SDCBP2 SERPINE2 SFN SLC16A3 SLPI SMARCB1 SMN1 SMN2 SNAP29 SNAP47 SNX20 SRRM4 STK3 SUCLA2 SURF6 SYT17 TBC1D25 TBRG4 TCEA2 TCEANC TGFBI TOM1L2 TRMT61B TSG101 TUFM TXN2 UBE2E2 URB1-AS1 WT1 YARS2 ZCCHC10 ZGPAT ZNF41 ZNF410 ZNF567 ZNF614	26 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 MMP14 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2
Entrez ID		171483	6590
HPRD ID		15955	00121
Ensembl ID		ENSG00000177138	ENSG00000124107
Uniprot IDs		Q8IZU0	P03973
PDB IDs			2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?		Protein Binding Mitochondrial Matrix RNA Binding	Collagen Catabolic Process Endolysosome Lumen Collagen Metabolic Process Cellular Response To Thyroid Hormone Stimulus Extracellular Matrix Disassembly Proteoglycan Binding Extracellular Matrix TRC Complex Positive Regulation Of ERAD Pathway Serine-type Endopeptidase Activity Peptidase Activity Proteolysis Extracellular Space Response To Thyroid Hormone Regulation Of ERAD Pathway Endopeptidase Activity Positive Regulation Of Proteolysis Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Protein Metabolic Process Determination Of Dorsal Identity Zymogen Activation Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Chemotaxis Regulation Of Immune System Process Sequestering Of Extracellular Ligand From Receptor Cysteine-type Endopeptidase Activity Regulation Of Cellular Response To Stress Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Collagen Binding Positive Regulation Of Defense Response To Bacterium Protein Processing Positive Regulation Of Protein Metabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Proteolysis Regulation Of Defense Response To Bacterium Catabolic Process Azurophil Granule Lumen Regulation Of Leukocyte Migration Regulation Of Response To Endoplasmic Reticulum Stress Hydrolase Activity ERAD Pathway Macromolecule Metabolic Process Regulation Of Immune Response Proteolysis Involved In Protein Catabolic Process BMP Binding
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