PSORS1C2 and VASP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSORS1C2	VASP
Description		psoriasis susceptibility 1 candidate 2	vasodilator stimulated phosphoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding
	Biological Process		Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization
Pathways			Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Broad depression or schizophrenia ( 30626913) Clostridioides difficle infection in antibiotics-users ( 33841421) Height ( 25282103 28552196) Hematology traits ( 23263863) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Metabolite levels ( 23823483) Multiple myeloma ( 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Night sleep phenotypes ( 27126917) Serum uric acid levels ( 30993211) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 21738480)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		27 interacting genes: AGR2 AP1B1 AP2B1 BANP CEP70 ERICH2 EVPL GUCA1C HMG20A HOMER3 LHX3 MED20 MEIS3 MYL2 MYL7 NCKIPSD PAX6 PEX19 REL RTRAF SERTAD1 SGTA SGTB TTC23 UBQLN1 UBQLN2 VASP	49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX
Entrez ID		170680	7408
HPRD ID		17921	03415
Ensembl ID		ENSG00000204538	ENSG00000125753
Uniprot IDs		A0A1U9X9A6 Q9UIG4	A0A024R0V4 P50552
PDB IDs			1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Clathrin Adaptor Complex A Band Cell Fate Specification Protein Targeting Identical Protein Binding ERAD Pathway Response To Endoplasmic Reticulum Stress Heart Contraction Positive Regulation Of Proteasomal Protein Catabolic Process Clathrin Binding Membrane Coat Heart Process Muscle Cell Fate Specification Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity	Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization
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