PSORS1C2 and EVPL

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
HPRD (in vivo)

		PSORS1C2	EVPL
Description		psoriasis susceptibility 1 candidate 2	envoplakin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding	Structural Molecule Activity Cadherin Binding
	Biological Process		Regulation Of Antibacterial Peptide Production Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Broad depression or schizophrenia ( 30626913) Clostridioides difficle infection in antibiotics-users ( 33841421) Height ( 25282103 28552196) Hematology traits ( 23263863) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Metabolite levels ( 23823483) Multiple myeloma ( 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Night sleep phenotypes ( 27126917) Serum uric acid levels ( 30993211) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 21738480)	Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		27 interacting genes: AGR2 AP1B1 AP2B1 BANP CEP70 ERICH2 EVPL GUCA1C HMG20A HOMER3 LHX3 MED20 MEIS3 MYL2 MYL7 NCKIPSD PAX6 PEX19 REL RTRAF SERTAD1 SGTA SGTB TTC23 UBQLN1 UBQLN2 VASP	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		170680	2125
HPRD ID		17921	03352
Ensembl ID		ENSG00000204538	ENSG00000167880
Uniprot IDs		A0A1U9X9A6 Q9UIG4	B7ZLH8 K7EKI0 Q92817
PDB IDs			4QMD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Clathrin Adaptor Complex A Band Cell Fate Specification Protein Targeting Identical Protein Binding ERAD Pathway Response To Endoplasmic Reticulum Stress Heart Contraction Positive Regulation Of Proteasomal Protein Catabolic Process Clathrin Binding Membrane Coat Heart Process Muscle Cell Fate Specification Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity	Cornified Envelope Peptide Cross-linking Keratinization Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Epidermal Cell Differentiation Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Epidermis Development Epithelial Cell Differentiation Keratin Filament Cytoskeleton Organization Protein Modification Process Structural Molecule Activity Wound Healing Supramolecular Fiber Organization Cytosol Extracellular Exosome Protein Heterotetramerization Tissue Development Protein Heterooligomerization Desmosome Positive Regulation Of Epidermis Development Response To Wounding Endopeptidase Inhibitor Activity Cytoplasm Protein Metabolic Process Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Polymerization Humoral Immune Response Antibacterial Humoral Response Regulation Of Epidermis Development Developmental Process Scaffold Protein Binding Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Copulation Organelle Organization Protein Tetramerization Peptidase Inhibitor Complex Peptidase Inhibitor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cellular Developmental Process Extracellular Space Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Keratinocyte Migration Cardiac Muscle Cell-cardiac Muscle Cell Adhesion
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