APBB1 and THRAP3

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		APBB1	THRAP3
Description		amyloid beta precursor protein binding family B member 1	thyroid hormone receptor associated protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Nuclear Speck Lamellipodium Growth Cone Cell Projection Synapse	Nucleus Nucleoplasm Mediator Complex Nuclear Speck Exon-exon Junction Complex Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Molecular Adaptor Activity Proline-rich Region Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding ATP Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Smooth Muscle Contraction DNA Damage Response Signal Transduction Axonogenesis Positive Regulation Of Neuron Projection Development Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Cell Cycle G1/S Phase Transition	Regulation Of Alternative MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing Circadian Rhythm RNA Splicing Positive Regulation Of Circadian Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Rhythmic Process
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Malaria ( 31844061)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		72 interacting genes: ABI1 ABL1 ALK ANXA1 APLP1 APLP2 APP ATM ATR ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNCA TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	13 interacting genes: APBB1 CEBPA CLK1 CSNK2A1 NEDD4 OGT PIN1 RNF10 SHANK3 SREK1 USP7 WEE2-AS1 YWHAG
Entrez ID		322	9967
HPRD ID		04087	07543
Ensembl ID		ENSG00000166313	ENSG00000054118
Uniprot IDs		B7Z4M9 O00213	Q9Y2W1
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing Nucleic Acid Binding RNA Metabolic Process RNA Binding Spliceosomal Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Actin Polymerization Or Depolymerization Nucleus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nuclear Speck Protein-RNA Complex Assembly SH3 Domain Binding MRNA Binding Catalytic Step 2 Spliceosome Protein-containing Complex Organization U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Cellular Component Assembly Regulation Of Primary Metabolic Process Nucleoplasm MRNA 3'-splice Site Recognition Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Actin Filament Organization Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Actin Binding Alternative MRNA Splicing, Via Spliceosome Profilin Binding Negative Regulation Of Metabolic Process Regulation Of RNA Splicing SCAR Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Lamellipodium Regulation Of Macromolecule Biosynthetic Process	Regulation Of Protein Catabolic Process Protein Localization To Vacuole Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Phosphothreonine Residue Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Phosphoserine Residue Binding Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting Negative Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Lysosome TORC1 Signaling Protein Stabilization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process TOR Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Cellular Response To Stress Regulation Of Translational Initiation Proline-rich Region Binding Signal Transduction Sin3-type Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Metabolic Process Regulation Of TOR Signaling Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization Response To Nutrient Levels Regulation Of Primary Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Catabolic Process
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