APBB1 and ALK

Number of citations: 30 (PubMedID 39115278)
Data Source: BioGRID (proximity labelling technology, biochemical, enzymatic study, proximity labelling technology)

		APBB1	ALK
Name		amyloid beta precursor protein binding family B member 1	ALK receptor tyrosine kinase
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Nuclear Speck Lamellipodium Growth Cone Cell Projection Synapse	Plasma Membrane Membrane Protein-containing Complex Receptor Complex Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Molecular Adaptor Activity Proline-rich Region Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Smooth Muscle Contraction DNA Damage Response Signal Transduction Axonogenesis Positive Regulation Of Neuron Projection Development Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Cell Cycle G1/S Phase Transition	Response To Stress Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Phosphorylation Hippocampus Development Adult Behavior Swimming Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026-resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib-resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants MDK and PTN in ALK signaling MDK and PTN in ALK signaling
Drugs		None	ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases		None	Non-small cell lung cancer
GWAS		Malaria ( 31844061 )	Adiponectin levels (BMI-adjusted) ( 26299439 ) Body mass index ( 25673413 ) Body size at age 10 ( 32376654 ) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027 ) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027 ) Dentures ( 31235808 ) Gestational age at birth (child effect) ( 31194736 ) Glucose homeostasis traits ( 25524916 ) Low density lipoprotein cholesterol levels ( 33339817 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Simvastatin-induced myopathy ( 31220337 ) Spontaneous coronary artery dissection ( 32887874 ) Systolic blood pressure ( 26969751 ) Total cholesterol levels ( 33339817 )
Interacting Genes		72 interacting genes: ABI1 ABL1 ALK ANXA1 APLP1 APLP2 APP ATM ATR ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNCA TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	19 interacting genes: APBB1 DUSP19 ERBB2 HES1 IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PPM1A PTN PTPN11 PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1
Entrez ID		322	238
HPRD ID		04087	00104
Ensembl ID		ENSG00000166313	ENSG00000171094
Uniprot IDs		B7Z4M9 O00213	A0A0K2YUJ3 B6D4Y2 Q9UM73
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH	2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7BTT 7JY4 7JYR 7JYS 7JYT 7LRZ 7LS0 7MZW 7MZY 7N00 7NWZ 7NX3 7NX4 7R7K 7R7R 8ARJ 9G5I 9GBE
GO Terms Enriched among Interactors		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing Nucleic Acid Binding RNA Metabolic Process RNA Binding Spliceosomal Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Actin Polymerization Or Depolymerization Nucleus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nuclear Speck Protein-RNA Complex Assembly SH3 Domain Binding MRNA Binding Catalytic Step 2 Spliceosome Protein-containing Complex Organization U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Cellular Component Assembly Regulation Of Primary Metabolic Process Nucleoplasm MRNA 3'-splice Site Recognition Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Actin Filament Organization Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Actin Binding Alternative MRNA Splicing, Via Spliceosome Profilin Binding Negative Regulation Of Metabolic Process Regulation Of RNA Splicing SCAR Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Lamellipodium Regulation Of Macromolecule Biosynthetic Process	Regulation Of Apoptotic Process Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Negative Regulation Of Apoptotic Process ERBB Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cell Adhesion Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Hemopoiesis Negative Regulation Of T Cell Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Receptor Tyrosine Kinase Binding Leukocyte Activation Positive Regulation Of Gliogenesis Intracellular Signal Transduction Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Glial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Immune System Process Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Negative Regulation Of Lymphocyte Activation Lymphocyte Activation Cell Activation Response To Growth Factor Negative Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Leukocyte Activation Insulin-like Growth Factor Receptor Signaling Pathway