APBB1 and CYFIP1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		APBB1	CYFIP1
Description		amyloid beta precursor protein binding family B member 1	cytoplasmic FMR1 interacting protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Nuclear Speck Lamellipodium Growth Cone Cell Projection Synapse	Ruffle Extracellular Region Cytoplasm Cytosol Focal Adhesion Lamellipodium SCAR Complex Cell Leading Edge Secretory Granule Lumen Specific Granule Lumen Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Tertiary Granule Lumen
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Molecular Adaptor Activity Proline-rich Region Binding	RNA 7-methylguanosine Cap Binding Actin Binding Protein Binding Translation Repressor Activity Small GTPase Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Smooth Muscle Contraction DNA Damage Response Signal Transduction Axonogenesis Positive Regulation Of Neuron Projection Development Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Cell Cycle G1/S Phase Transition	Cell Morphogenesis Regulation Of Translation Nervous System Development Axon Guidance Regulation Of Cell Shape Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Negative Regulation Of Translation Lamellipodium Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Neuron Projection Development Ruffle Organization Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Malaria ( 31844061)	Bipolar disorder ( 34099189) Heel bone mineral density ( 30598549) Platelet distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) World class endurance athleticism ( 32612638)
Interacting Genes		72 interacting genes: ABI1 ABL1 ALK ANXA1 APLP1 APLP2 APP ATM ATR ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNCA TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 EIF4E FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1
Entrez ID		322	23191
HPRD ID		04087	05890
Ensembl ID		ENSG00000166313	ENSG00000273749
Uniprot IDs		B7Z4M9 O00213	Q7L576
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH	3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing Nucleic Acid Binding RNA Metabolic Process RNA Binding Spliceosomal Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Actin Polymerization Or Depolymerization Nucleus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nuclear Speck Protein-RNA Complex Assembly SH3 Domain Binding MRNA Binding Catalytic Step 2 Spliceosome Protein-containing Complex Organization U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Cellular Component Assembly Regulation Of Primary Metabolic Process Nucleoplasm MRNA 3'-splice Site Recognition Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Actin Filament Organization Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Actin Binding Alternative MRNA Splicing, Via Spliceosome Profilin Binding Negative Regulation Of Metabolic Process Regulation Of RNA Splicing SCAR Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Lamellipodium Regulation Of Macromolecule Biosynthetic Process	Cell Projection Morphogenesis Neuron Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Postsynapse Nuclear Speck MRNA Transport RNA Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Nucleobase-containing Compound Transport RNA Export From Nucleus Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cytoplasmic Stress Granule RNA Binding Developmental Process Modulation Of Chemical Synaptic Transmission Translation Regulator Activity Intracellular Signaling Cassette Nuclear Export Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Secretion Protein-containing Complex Binding Neuron Differentiation RNA Splicing Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Dendritic Spine Development Presynaptic Modulation Of Chemical Synaptic Transmission Cell Projection Organization Eukaryotic Initiation Factor 4G Binding Positive Regulation Of Intracellular Transport Of Viral Material Telomere Tethering At Nuclear Periphery Secretin Receptor Activity Pancreatic Epsilon Cell Differentiation Lamellipodium MRNA Processing Molecular Condensate Scaffold Activity Regulation Of Dendritic Spine Development Dendritic Filopodium Positive Regulation Of Neurogenesis Histone H3 Reader Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Pancreatic D Cell Differentiation
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