APBB1 and TENM1

Number of citations of the paper that reports this interaction (PubMedID 25648896)
70

Data Source:
BioGRID (two hybrid)

		APBB1	TENM1
Description		amyloid beta precursor protein binding family B member 1	teneurin transmembrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Nuclear Speck Lamellipodium Growth Cone Cell Projection Synapse	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytoskeleton Plasma Membrane Membrane Nuclear Matrix Nuclear Speck Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Molecular Adaptor Activity Proline-rich Region Binding	Heparin Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Smooth Muscle Contraction DNA Damage Response Signal Transduction Axonogenesis Positive Regulation Of Neuron Projection Development Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Cell Cycle G1/S Phase Transition	Regulation Of Transcription By RNA Polymerase III Immune Response Signal Transduction Neuropeptide Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of MAP Kinase Activity Neuron Development Positive Regulation Of Filopodium Assembly Positive Regulation Of Intracellular Protein Transport
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		72 interacting genes: ABI1 ABL1 ALK ANXA1 APLP1 APLP2 APP ATM ATR ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNCA TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	12 interacting genes: APBB1 BEX1 CSNK2B FIBP MACF1 MBD1 NUBP1 PICALM POLR2J PTPN12 RACK1 SORBS1
Entrez ID		322	10178
HPRD ID		04087	06669
Ensembl ID		ENSG00000166313	ENSG00000009694
Uniprot IDs		B7Z4M9 O00213	B7ZMH4 Q9UKZ4
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing Nucleic Acid Binding RNA Metabolic Process RNA Binding Spliceosomal Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Actin Polymerization Or Depolymerization Nucleus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nuclear Speck Protein-RNA Complex Assembly SH3 Domain Binding MRNA Binding Catalytic Step 2 Spliceosome Protein-containing Complex Organization U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Cellular Component Assembly Regulation Of Primary Metabolic Process Nucleoplasm MRNA 3'-splice Site Recognition Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Actin Filament Organization Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Actin Binding Alternative MRNA Splicing, Via Spliceosome Profilin Binding Negative Regulation Of Metabolic Process Regulation Of RNA Splicing SCAR Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Lamellipodium Regulation Of Macromolecule Biosynthetic Process	Low-density Lipoprotein Particle Receptor Binding Nucleus Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane
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