APBB1 and RPL4

Number of citations: 76 (PubMedID 16055720)
Data Source: BioGRID (pull down)

		APBB1	RPL4
Name		amyloid beta precursor protein binding family B member 1	ribosomal protein L4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Nuclear Speck Lamellipodium Growth Cone Cell Projection Synapse	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Nuclear Body Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Molecular Adaptor Activity Proline-rich Region Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Apoptotic Process Smooth Muscle Contraction DNA Damage Response Signal Transduction Axonogenesis Positive Regulation Of Neuron Projection Development Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Cell Cycle G1/S Phase Transition	Cytoplasmic Translation Translation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		None	Artenimol
GWAS		Malaria ( 31844061 )	No GWAS studies recorded
Interacting Genes		72 interacting genes: ABI1 ABL1 ALK ANXA1 APLP1 APLP2 APP ATM ATR ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNCA TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	21 interacting genes: APBB1 APOE DUX4 DUX4L9 FOXP1 IL32 MAP3K14 MDM2 MYB NDRG1 OGT PBX2 PIN1 PRDX2 PRPF40A RBFOX2 SF3B6 SORBS1 SUMO2 TNPO2 TSC2
Entrez ID		322	6124
HPRD ID		04087	01607
Ensembl ID		ENSG00000166313	ENSG00000174444
Uniprot IDs		B7Z4M9 O00213	P36578
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH	4UG0 4V6X 5A8L 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO
GO Terms Enriched among Interactors		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing Nucleic Acid Binding RNA Metabolic Process RNA Binding Spliceosomal Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Actin Polymerization Or Depolymerization Nucleus Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Nuclear Speck Protein-RNA Complex Assembly SH3 Domain Binding MRNA Binding Catalytic Step 2 Spliceosome Protein-containing Complex Organization U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Cellular Component Assembly Regulation Of Primary Metabolic Process Nucleoplasm MRNA 3'-splice Site Recognition Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Actin Filament Organization Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Actin Binding Alternative MRNA Splicing, Via Spliceosome Profilin Binding Negative Regulation Of Metabolic Process Regulation Of RNA Splicing SCAR Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Lamellipodium Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Lipid Biosynthetic Process SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Signal Transduction Low-density Lipoprotein Particle Receptor Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Phospholipid Efflux Regulation Of Wnt Signaling Pathway Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cell Population Proliferation Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Negative Regulation Of Signaling Negative Regulation Of Developmental Process Antioxidant Activity Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Protein Metabolic Process