DGKH and TRAF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DGKH	TRAF5
Description		diacylglycerol kinase eta	TNF receptor associated factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Actin Cytoskeleton Membrane Protein-containing Complex	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding SAM Domain Binding Identical Protein Binding Metal Ion Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Phospholipase C/protein Kinase C Signal Transduction	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway
Pathways		Effects of PIP2 hydrolysis
Drugs		alpha-Tocopherol succinate
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 17486107) Blood urea nitrogen levels ( 29403010) Body size at age 10 ( 32376654) Calcium levels ( 24068962) Cortisol levels (saliva) ( 28843169) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Height ( 20189936) Kidney stones ( 31729369) Metabolite levels (X-11787) ( 23934736) Nephrolithiasis ( 22396660) Plasma anti-thyroglobulin levels ( 29678681) Pulmonary function in asthmatics ( 25221879) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)	Household income (MTAG) ( 31844048)
Interacting Genes		2 interacting genes: DGKD TRAF5	63 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 CDC37 CIB3 COMMD3 DGKH DRC4 ENOX2 FAM9A GOLGA2 GORASP2 HSD17B10 HSF2BP LMO4 LNX1 LTBR MAP3K14 MAP3K5 MDM2 MEOX2 NMI NTAQ1 NUMBL ODF2 PIAS2 PIBF1 PICK1 PSMA1 RAD23A RIPK1 RIPK2 RNF111 RNF4 SDCBP SEC13 SERPINB9 SUMO1 TBK1 TDP2 THAP1 THAP7 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 YPEL5 ZFAND6 ZNF655
Entrez ID		160851	7188
HPRD ID		07237	03834
Ensembl ID		ENSG00000102780	ENSG00000082512
Uniprot IDs		A8K0I1 B4DYW1 Q86XP1	O00463
PDB IDs			7L3L
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Response To Norepinephrine Phosphatidylinositol 3-kinase Activator Activity Cellular Response To Endothelin Positive Regulation Of Sarcomere Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Cellular Response To Hydroperoxide Cellular Response To Norepinephrine Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Phorbol 13-acetate 12-myristate Regulation Of Endocytosis Regulation Of Sarcomere Organization Thioesterase Binding CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis Diacylglycerol Catabolic Process Lipid Phosphorylation ATP-dependent Diacylglycerol Kinase Activity Response To Endothelin CD40 Receptor Complex Positive Regulation Of Cell Size Response To Phorbol 13-acetate 12-myristate Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Diacylglycerol Binding Zinc Ion Binding Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Hydroperoxide Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Protein Export From Nucleus Cellular Response To Catecholamine Stimulus Response To Catecholamine Cellular Response To Angiotensin Regulation Of Skeletal Muscle Contraction Identical Protein Binding Diacylglycerol Metabolic Process Regulation Of Clathrin-dependent Endocytosis Lipid Biosynthetic Process Regulation Of Vesicle-mediated Transport Response To Angiotensin	Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction PML Body Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Immune Response CD40 Signaling Pathway Protein Modification Process Protein Ubiquitination Post-translational Protein Modification Cytokine-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity CD40 Receptor Complex Ubiquitin Protein Ligase Activity Protein Polyubiquitination Identical Protein Binding Protein K63-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cytoplasm Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Cell Activation Ubiquitin-protein Transferase Activity JUN Kinase Kinase Kinase Activity Regulation Of Cytokine-mediated Signaling Pathway Protein Metabolic Process Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Positive Regulation Of Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Response To Stress Protein Autoubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Signaling Adaptor Activity Intracellular Signaling Cassette Positive Regulation Of Cell Communication Adaptive Immune Response
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