DGKH

Description		diacylglycerol kinase eta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Actin Cytoskeleton Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding SAM Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Phospholipase C/protein Kinase C Signal Transduction
Pathways		Effects of PIP2 hydrolysis
Drugs		alpha-Tocopherol succinate
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 17486107) Blood urea nitrogen levels ( 29403010) Body size at age 10 ( 32376654) Calcium levels ( 24068962) Cortisol levels (saliva) ( 28843169) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Height ( 20189936) Kidney stones ( 31729369) Metabolite levels (X-11787) ( 23934736) Nephrolithiasis ( 22396660) Plasma anti-thyroglobulin levels ( 29678681) Pulmonary function in asthmatics ( 25221879) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)
Novel Interacting Genes		2 novel interacting genes: CCDC122 PRKD1
Interacting Genes		2 interacting genes: DGKD TRAF5
Entrez ID		160851
HPRD ID		07237
Ensembl ID		ENSG00000102780
Uniprot IDs		A8K0I1 B4DYW1 Q86XP1
PDB IDs
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Response To Norepinephrine Phosphatidylinositol 3-kinase Activator Activity Cellular Response To Endothelin Positive Regulation Of Sarcomere Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Cellular Response To Hydroperoxide Cellular Response To Norepinephrine Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Phorbol 13-acetate 12-myristate Regulation Of Endocytosis Regulation Of Sarcomere Organization Thioesterase Binding CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis Diacylglycerol Catabolic Process Lipid Phosphorylation ATP-dependent Diacylglycerol Kinase Activity Response To Endothelin CD40 Receptor Complex Positive Regulation Of Cell Size Response To Phorbol 13-acetate 12-myristate Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Diacylglycerol Binding Zinc Ion Binding Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Hydroperoxide Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Protein Export From Nucleus Cellular Response To Catecholamine Stimulus Response To Catecholamine Cellular Response To Angiotensin Regulation Of Skeletal Muscle Contraction Identical Protein Binding Diacylglycerol Metabolic Process Regulation Of Clathrin-dependent Endocytosis Lipid Biosynthetic Process Regulation Of Vesicle-mediated Transport Response To Angiotensin
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