DGKH and DGKD

Number of citations of the paper that reports this interaction (PubMedID 12810723)
0

Data Source:
HPRD (in vivo)

		DGKH	DGKD
Description		diacylglycerol kinase eta	diacylglycerol kinase delta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Actin Cytoskeleton Membrane Protein-containing Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding SAM Domain Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Phospholipase C/protein Kinase C Signal Transduction	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Diacylglycerol Catabolic Process Phosphatidic Acid Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis
Pathways		Effects of PIP2 hydrolysis	Effects of PIP2 hydrolysis
Drugs		alpha-Tocopherol succinate	Phosphatidyl serine alpha-Tocopherol succinate
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 17486107) Blood urea nitrogen levels ( 29403010) Body size at age 10 ( 32376654) Calcium levels ( 24068962) Cortisol levels (saliva) ( 28843169) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate ( 29403010) Height ( 20189936) Kidney stones ( 31729369) Metabolite levels (X-11787) ( 23934736) Nephrolithiasis ( 22396660) Plasma anti-thyroglobulin levels ( 29678681) Pulmonary function in asthmatics ( 25221879) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)	Appendicular lean mass ( 33097823) Bilirubin levels ( 20639394 32084209) Calcium levels ( 20705733 24068962 29403010) Crohn's disease ( 22412388) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30718926 32499647) Urinary calcium excretion ( 31993563)
Interacting Genes		2 interacting genes: DGKD TRAF5	10 interacting genes: DGKH DYSF FMR1 FXR2 HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14
Entrez ID		160851	8527
HPRD ID		07237	03492
Ensembl ID		ENSG00000102780	ENSG00000077044
Uniprot IDs		A8K0I1 B4DYW1 Q86XP1	Q16760
PDB IDs			1R79 3BQ7
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Response To Norepinephrine Phosphatidylinositol 3-kinase Activator Activity Cellular Response To Endothelin Positive Regulation Of Sarcomere Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Cellular Response To Hydroperoxide Cellular Response To Norepinephrine Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Phorbol 13-acetate 12-myristate Regulation Of Endocytosis Regulation Of Sarcomere Organization Thioesterase Binding CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis Diacylglycerol Catabolic Process Lipid Phosphorylation ATP-dependent Diacylglycerol Kinase Activity Response To Endothelin CD40 Receptor Complex Positive Regulation Of Cell Size Response To Phorbol 13-acetate 12-myristate Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Diacylglycerol Binding Zinc Ion Binding Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Hydroperoxide Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Protein Export From Nucleus Cellular Response To Catecholamine Stimulus Response To Catecholamine Cellular Response To Angiotensin Regulation Of Skeletal Muscle Contraction Identical Protein Binding Diacylglycerol Metabolic Process Regulation Of Clathrin-dependent Endocytosis Lipid Biosynthetic Process Regulation Of Vesicle-mediated Transport Response To Angiotensin	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Positive Regulation Of Cell Development Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of MRNA Stability Regulation Of RNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Nervous System Development Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Intracellular Transport Of Viral Material Positive Regulation Of Myeloid Leukocyte Differentiation Monocyte Activation Involved In Immune Response Dendritic Filopodium Cytoplasmic Ribonucleoprotein Granule Regulation Of Cell Development Regulation Of Neurotransmitter Secretion Signaling Adaptor Activity Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Differentiation Histone H3 Reader Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Adaptive Immune Memory Response SAM Domain Binding Regulation Of Translation Negative Regulation Of Long-term Synaptic Depression Cytoplasmic Stress Granule Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Regulation Of Nervous System Development Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Myeloid Leukocyte Differentiation Protein Kinase C Signaling MRNA Transport MRNA 3'-UTR Binding RNA Strand Annealing Activity Presynaptic Membrane Regulation Of Neuronal Action Potential Regulation Of Angiotensin-activated Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway Neuronal Ribonucleoprotein Granule Negative Regulation Of Synaptic Vesicle Exocytosis RNA Transport Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Vesicle-mediated Transport
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