RAB11FIP2 and CXCR2

Number of citations of the paper that reports this interaction (PMID 15004234)
40

Data Source:
HPRD (in vivo)

		RAB11FIP2	CXCR2
Gene Name		RAB11 family interacting protein 2 (class I)	chemokine (C-X-C motif) receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Endosome Plasma Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Mast Cell Granule
	Molecular Function	Protein Binding Rab GTPase Binding Protein Kinase Binding Protein Homodimerization Activity	Signal Transducer Activity Interleukin-8 Receptor Activity Protein Binding C-X-C Chemokine Receptor Activity Interleukin-8 Binding
	Biological Process	Renal Water Homeostasis Water Transport Protein Transport Establishment Of Cell Polarity Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulated Secretory Pathway Transmembrane Transport	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Aquaporin-mediated transport	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		12 interactors: AP2A1 CXCR2 EHD1 ITSN1 MARK2 MYO5B RAB11A RAB11B RAB11FIP4 RAB25 REPS1 YWHAG	21 interactors: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13
Entrez ID		22841	3579
HPRD ID		10548	00907
Ensembl ID		ENSG00000107560	ENSG00000180871
Uniprot IDs		Q3I768 Q7L804	P25025 Q53PC4
PDB IDs		2GZD 2GZH 2K6S 3TSO 4C4P
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Organelle Localization Cellular Localization Transport Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Regulation Of Endocytic Recycling Protein Transport Establishment Of Protein Localization Establishment Of Vesicle Localization Intracellular Protein Transport Endosomal Transport Vesicle Localization Cellular Pigmentation Rab Protein Signal Transduction Endocytosis Protein Localization Establishment Of Organelle Localization Establishment Of Localization In Cell Cellular Protein Localization Pigmentation Regulation Of Vesicle-mediated Transport Chemical Homeostasis Nervous System Development Intracellular Transport Generation Of Neurons Neurogenesis Renal Water Homeostasis Intracellular Signal Transduction Cellular Response To Organic Substance Cell Projection Organization Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Water Transport Fluid Transport Multicellular Organismal Water Homeostasis Homeostatic Process Water Homeostasis Cell Differentiation Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Neutrophil Apoptotic Process Multivesicular Body Assembly Regulation Of Multivesicular Body Size Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Cellular Component Movement Receptor-mediated Endocytosis	Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Behavior Inflammatory Response Cytokine-mediated Signaling Pathway Signaling Cell Communication Response To Lipopolysaccharide Receptor Metabolic Process Positive Regulation Of Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Platelet Activation Positive Regulation Of Locomotion Signal Transduction Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Chemotaxis Cellular Response To Stimulus Receptor Internalization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Cytokine Response To External Stimulus Response To Bacterium G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Migration Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility Response To Stress Regulation Of Locomotion Cell Activation Blood Coagulation Cellular Response To Organic Substance Regulation Of Cellular Component Movement Hemostasis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Other Organism Response To Stimulus Regulation Of Cell Proliferation Response To Biotic Stimulus
Tagcloud ?			ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Difference) ?			ab attenuating chemokine chemokines chemotactic cxcr1 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic
Tagcloud (Intersection) ?