RAB11FIP2 and RAB25

Number of citations of the paper that reports this interaction (PubMedID 37232246)
61

Data Source:
BioGRID (proximity labelling technology)
HPRD (two hybrid)

		RAB11FIP2	RAB25
Description		RAB11 family interacting protein 2	RAB25, member RAS oncogene family
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GO Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Endosome Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cell Projection Recycling Endosome Membrane	Golgi Apparatus Plasma Membrane Membrane Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Cell Projection Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding
	Biological Process	Phagocytosis Cell Communication Protein Transport Vesicle-mediated Transport Signaling Establishment Of Cell Polarity TRAM-dependent Toll-like Receptor 4 Signaling Pathway Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of GTPase Activity Regulated Exocytosis Positive Regulation Of Protein Localization To Plasma Membrane	Epithelial Cell Morphogenesis Exocytosis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Migration Protein Transport Pseudopodium Organization Regulation Of Vesicle-mediated Transport
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins	RAB geranylgeranylation
Drugs
Diseases
GWAS		Age spots ( 29895819) Asthma (sex interaction) ( 24824216) Celiac disease ( 23936387) Freckles ( 29895819) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 29403010 30993211)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Parkinson's disease ( 32201043)
Interacting Genes		22 interacting genes: AP2A1 CXCR2 EHD1 FAM90A1 FBXO17 FKBP6 HSF2BP ITSN1 KANK2 LRRK2 MARK2 MYO5B OGT PIBF1 RAB11A RAB11B RAB11FIP4 RAB25 REPS1 SNCA YWHAE YWHAG	14 interacting genes: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SH3BP5L SMAD4 SMURF2 TGFBR1
Entrez ID		22841	57111
HPRD ID		10548	06698
Ensembl ID		ENSG00000107560	ENSG00000132698
Uniprot IDs		Q7L804	P57735
PDB IDs		2GZD 2GZH 2K6S 3TSO 4C4P 6S8X	2OIL 3TSO
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endosomal Transport Endocytosis Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Import Into Cell Intracellular Protein Localization Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Intracellular Transport Myosin V Binding Organelle Localization Establishment Of Protein Localization Regulation Of Endocytic Recycling Endocytic Recycling Regulation Of Biological Quality Vesicle-mediated Transport In Synapse Exocytosis Recycling Endosome Membrane Cellular Localization Secretion By Cell Establishment Of Vesicle Localization Protein Localization To Organelle Synaptic Vesicle Endocytosis Vesicle Localization Protein Sequestering Activity Regulation Of Intracellular Transport Presynaptic Endocytosis Synaptic Vesicle Membrane Synaptic Vesicle Amyloid-beta Clearance By Transcytosis Regulation Of Synapse Organization Secretion Protein Transport Cytoplasm Regulation Of Cellular Localization Positive Regulation Of Endocytosis Postsynaptic Endocytic Zone Glutamatergic Synapse Receptor-mediated Endocytosis GTP Binding Receptor Internalization Regulation Of Transport Clathrin-coated Pit G Protein Activity Regulation Of Protein Localization Protein-macromolecule Adaptor Activity Regulation Of SNARE Complex Assembly Phagocytic Vesicle Protein Localization To Endoplasmic Reticulum	SMAD Binding Recycling Endosome Negative Regulation Of Adiponectin Secretion Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Endosome Recycling Endosome Membrane Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Small GTPase Binding Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Pattern Specification Process BMP Receptor Activity Positive Regulation Of Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Vesicle-mediated Transport Negative Regulation Of Hormone Secretion Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Negative Regulation Of Protein Secretion Activin Binding BMP Signaling Pathway In Utero Embryonic Development Insulin Secretion Involved In Cellular Response To Glucose Stimulus Chordate Embryonic Development Regulation Of Hormone Secretion Regulation Of Hormone Levels Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Cellular Response To Growth Factor Stimulus I-SMAD Binding Gastrulation With Mouth Forming Second Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulated Exocytosis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Communication Pharyngeal System Development Regulation Of Signaling
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