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FAM154A and CRK
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
FAM154A
CRK
Gene Name
family with sequence similarity 154, member A
v-crk avian sarcoma virus CT10 oncogene homolog
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
SH3/SH2 Adaptor Activity
Protein Binding
SH2 Domain Binding
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Biological Process
Activation Of MAPKK Activity
Regulation Of Transcription From RNA Polymerase II Promoter
Blood Coagulation
Insulin Receptor Signaling Pathway
Platelet Activation
Regulation Of Rho GTPase Activity
Regulation Of Actin Cytoskeleton Organization
Regulation Of Rac Protein Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Pathways
Signalling to ERKs
Prolonged ERK activation events
Platelet Aggregation (Plug Formation)
VEGFA-VEGFR2 Pathway
Regulation of signaling by CBL
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Signaling by Insulin receptor
Innate Immune System
Signaling by PDGF
Signalling by NGF
Insulin receptor signalling cascade
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
Cytokine Signaling in Immune system
NGF signalling via TRKA from the plasma membrane
ARMS-mediated activation
Signaling by Interleukins
Signal attenuation
Signaling by VEGF
Downstream signal transduction
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Non-small cell lung cancer (
23144319
)
Protein-Protein Interactions
18 interactors:
ACTN2
CRK
FAM124A
FHL2
FHL3
GLYCTK
HOXA1
KIR3DX1
LMO1
LMO2
MVP
OSGIN1
POLR1C
SORBS3
STK16
TRIP6
VPS28
ZMYND19
84 interactors:
ABL1
ABL2
ARHGAP17
ARHGAP32
ASAP1
ATXN1
AVIL
BCAR1
BCR
BUB1
CBL
CBLC
CRKL
DAB1
DOCK1
DOCK3
DOK1
DOK4
DPPA4
EFS
EGFR
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
ERBB2
ERBB3
ERBB4
FAM154A
FASLG
FGFR1
FLT1
FRS2
FYN
GAB1
GRB2
IGF1R
INSR
IRS1
IRS2
IRS4
KDR
KHDRBS1
KIT
MAP4K1
MAP4K5
MAPK4
MAPK8
MICAL1
NCK1
NEDD9
NTRK1
PDGFRA
PDGFRB
PIK3R1
PLSCR1
POT1
PPFIBP2
PPP1CA
PSMC6
PTK2
PTK2B
PTPN1
PTPN4
PXN
RAPGEF1
REPS1
RET
SH3BP1
SHB
SHC1
SOCS1
SOS1
SPRR2A
STAT5A
STAT5B
SYN1
TERF2IP
VAV1
WASF1
WEE1
XPO1
ZAP70
Entrez ID
158297
1398
HPRD ID
16676
01267
Ensembl ID
ENSG00000155875
ENSG00000167193
Uniprot IDs
F6S232
Q8IYX7
L7RT18
P46108
PDB IDs
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
Enriched GO Terms of Interacting Partners
?
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Focal Adhesion Assembly
Cell-substrate Adhesion
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Adherens Junction Assembly
Regulation Of RNA Metabolic Process
Cell-substrate Junction Assembly
Positive Regulation Of Cellular Metabolic Process
Optokinetic Behavior
Abducens Nerve Formation
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Facial Nucleus Development
Adherens Junction Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription, DNA-templated
Positive Regulation Of Gene Expression
Rhombomere 4 Development
Atrial Cardiac Muscle Cell Development
Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Semicircular Canal Formation
Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Rhombomere 3 Development
Rhombomere 5 Development
Positive Regulation Of Metabolic Process
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Release Of Cytoplasmic Sequestered NF-kappaB
Endosome Transport Via Multivesicular Body Sorting Pathway
Microspike Assembly
Late Endosome To Vacuole Transport
Cell-matrix Adhesion
Negative Regulation Of Protein Localization To Cell Surface
Embryonic Neurocranium Morphogenesis
Platelet Activation
Negative Regulation Of Erythrocyte Differentiation
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Outer Ear Morphogenesis
Actin Filament-based Process
Cell Junction Assembly
Semicircular Canal Morphogenesis
Rhombomere Development
Cellular Response To Thyroid Hormone Stimulus
Viral Protein Processing
Negative Regulation Of Cellular Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signaling
ERBB Signaling Pathway
Regulation Of Signal Transduction
Signaling
Positive Regulation Of Signal Transduction
Signal Transduction
Cell Communication
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Intracellular Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Intracellular Signal Transduction
Regulation Of Catalytic Activity
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Stimulus
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Organic Substance
Positive Regulation Of Catalytic Activity
Protein Autophosphorylation
Fc Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Stimulus
Cellular Response To Organonitrogen Compound
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Phosphorylation
Response To Organic Substance
Phosphatidylinositol-mediated Signaling
Regulation Of Immune Response
Protein Phosphorylation
Cellular Response To Fibroblast Growth Factor Stimulus
Peptidyl-amino Acid Modification
Immune Response-regulating Signaling Pathway
Response To Fibroblast Growth Factor
Positive Regulation Of Metabolic Process
Regulation Of Phosphorus Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of MAPK Cascade
Immune System Process
Positive Regulation Of Transferase Activity
Phosphorylation
Cellular Response To Peptide
Positive Regulation Of MAPK Cascade
Fc-epsilon Receptor Signaling Pathway
Innate Immune Response
Tagcloud
?
abundantly
adhesions
arises
associating
carboxy
cas
conferring
connect
coordinating
dim1p
efs
encompassed
encompasses
fyn
hef1
identifies
interactor
localize
multidomain
oncoproteins
p105
p115
p130
p55
sh3
sin
spindle
sum
unexpectedly
Tagcloud (Difference)
?
abundantly
adhesions
arises
associating
carboxy
cas
conferring
connect
coordinating
dim1p
efs
encompassed
encompasses
fyn
hef1
identifies
interactor
localize
multidomain
oncoproteins
p105
p115
p130
p55
sh3
sin
spindle
sum
unexpectedly
Tagcloud (Intersection)
?