LRATD2 and AP1M1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRATD2	AP1M1
Description		LRAT domain containing 2	adaptor related protein complex 1 subunit mu 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process		Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly
Pathways			Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases
GWAS			Coronary artery disease ( 33020668)
Interacting Genes		14 interacting genes: ADRB2 AP1M1 BAG4 CTNNA1 DDIT4L ESR2 FGFR4 NOTCH2 PALB2 PTPN1 SMAD4 TAX1BP1 UROD XRCC3	103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16
Entrez ID		157638	8907
HPRD ID		11403	04639
Ensembl ID		ENSG00000168672	ENSG00000072958
Uniprot IDs		Q96KN1	B3KNH5 Q59EK3 Q9BXS5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of MAPK Cascade Protein-containing Complex Binding Enzyme Binding Positive Regulation Of MAPK Cascade Receptor Complex Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of Signal Transduction Negative Regulation Of Growth Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Animal Organ Morphogenesis Ovarian Follicle Development Negative Regulation Of Cardiac Myofibril Assembly Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Uroporphyrinogen Decarboxylase Activity Negative Regulation Of MRNA Modification In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Mesoderm Development Chordate Embryonic Development Cardiac Muscle Tissue Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of MiRNA Metabolic Process Response To Stress Beta2-adrenergic Receptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Extracellular Matrix Organization Cardiac Septum Morphogenesis	Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process
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