LRATD2 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		LRATD2	PALB2
Description		LRAT domain containing 2	partner and localizer of BRCA2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex
	Molecular Function	Protein Binding	DNA Binding Protein Binding
	Biological Process		Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway
Drugs
Diseases			Fanconi anemia
GWAS			Bipolar disorder ( 17554300)
Interacting Genes		14 interacting genes: ADRB2 AP1M1 BAG4 CTNNA1 DDIT4L ESR2 FGFR4 NOTCH2 PALB2 PTPN1 SMAD4 TAX1BP1 UROD XRCC3	31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3
Entrez ID		157638	79728
HPRD ID		11403	07966
Ensembl ID		ENSG00000168672	ENSG00000083093
Uniprot IDs		Q96KN1	A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2
PDB IDs			2W18 3EU7 7S4A 8YAP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of MAPK Cascade Protein-containing Complex Binding Enzyme Binding Positive Regulation Of MAPK Cascade Receptor Complex Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of Signal Transduction Negative Regulation Of Growth Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Animal Organ Morphogenesis Ovarian Follicle Development Negative Regulation Of Cardiac Myofibril Assembly Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Uroporphyrinogen Decarboxylase Activity Negative Regulation Of MRNA Modification In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Mesoderm Development Chordate Embryonic Development Cardiac Muscle Tissue Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of MiRNA Metabolic Process Response To Stress Beta2-adrenergic Receptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Extracellular Matrix Organization Cardiac Septum Morphogenesis	Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I
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