LRATD2 and XRCC3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		LRATD2	XRCC3
Description		LRAT domain containing 2	X-ray repair cross complementing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process		Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		14 interacting genes: ADRB2 AP1M1 BAG4 CTNNA1 DDIT4L ESR2 FGFR4 NOTCH2 PALB2 PTPN1 SMAD4 TAX1BP1 UROD XRCC3	22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7
Entrez ID		157638	7517
HPRD ID		11403	07201
Ensembl ID		ENSG00000168672	ENSG00000126215
Uniprot IDs		Q96KN1	O43542 Q53XC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of MAPK Cascade Protein-containing Complex Binding Enzyme Binding Positive Regulation Of MAPK Cascade Receptor Complex Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of Signal Transduction Negative Regulation Of Growth Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Animal Organ Morphogenesis Ovarian Follicle Development Negative Regulation Of Cardiac Myofibril Assembly Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Uroporphyrinogen Decarboxylase Activity Negative Regulation Of MRNA Modification In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Mesoderm Development Chordate Embryonic Development Cardiac Muscle Tissue Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of MiRNA Metabolic Process Response To Stress Beta2-adrenergic Receptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Extracellular Matrix Organization Cardiac Septum Morphogenesis	Recombinational Repair DNA Strand Invasion Double-strand Break Repair Via Homologous Recombination DNA Recombination Reciprocal Meiotic Recombination Homologous Recombination Double-strand Break Repair Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Shu Complex Mitotic Recombination DNA Metabolic Process DNA Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Recombinase Assembly Interstrand Cross-link Repair DNA Damage Response Meiosis I Cell Cycle Process Four-way Junction DNA Binding Telomere Maintenance Single-stranded DNA Binding Nucleic Acid Metabolic Process Telomere Organization Replication Fork ATP-dependent Activity, Acting On DNA Reproductive Process Growth Factor Activity Response To Glucoside Chromosome Organization Meiosis I Female Meiosis Sister Chromatid Cohesion Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Condensed Nuclear Chromosome Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Chromosome Organization Involved In Meiotic Cell Cycle Presynaptic Intermediate Filament Cytoskeleton Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Mesoderm Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Macrophage Homeostasis Cellular Response To Stress Nucleobase-containing Compound Metabolic Process
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