LRATD2 and UROD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LRATD2	UROD
Description		LRAT domain containing 2	uroporphyrinogen decarboxylase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Uroporphyrinogen Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity
	Biological Process		Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Porphyrin-containing Compound Catabolic Process Heme Metabolic Process Heme O Biosynthetic Process
Pathways			Heme biosynthesis
Drugs			Coproporphyrin I Coproporphyrinogen III
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS
Interacting Genes		14 interacting genes: ADRB2 AP1M1 BAG4 CTNNA1 DDIT4L ESR2 FGFR4 NOTCH2 PALB2 PTPN1 SMAD4 TAX1BP1 UROD XRCC3	11 interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA RUNX1 TSSK3 VIM
Entrez ID		157638	7389
HPRD ID		11403	01441
Ensembl ID		ENSG00000168672	ENSG00000126088
Uniprot IDs		Q96KN1	A0A494C0Q8 P06132
PDB IDs			1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of MAPK Cascade Protein-containing Complex Binding Enzyme Binding Positive Regulation Of MAPK Cascade Receptor Complex Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of Signal Transduction Negative Regulation Of Growth Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Animal Organ Morphogenesis Ovarian Follicle Development Negative Regulation Of Cardiac Myofibril Assembly Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Uroporphyrinogen Decarboxylase Activity Negative Regulation Of MRNA Modification In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Mesoderm Development Chordate Embryonic Development Cardiac Muscle Tissue Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of MiRNA Metabolic Process Response To Stress Beta2-adrenergic Receptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Extracellular Matrix Organization Cardiac Septum Morphogenesis	Positive Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Replication Multivesicular Body, Internal Vesicle Lumen Chondroitin Sulfate Proteoglycan Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Lymphocyte Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?