FAM84B and UROD

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FAM84B	UROD
Gene Name		family with sequence similarity 84, member B	uroporphyrinogen decarboxylase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Uroporphyrinogen Decarboxylase Activity
	Biological Process		Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Small Molecule Metabolic Process
Pathways			Heme biosynthesis Metabolism of porphyrins
Drugs			Coproporphyrin I Coproporphyrin Iii
Diseases
GWAS		Age-related macular degeneration ( 23326517) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: CTNNA1 UROD	6 interactors: CHD3 EGFR FAF1 FAM84B HMGXB4 VIM
Entrez ID		157638	7389
HPRD ID		11403	01441
Ensembl ID		ENSG00000168672	ENSG00000126088
Uniprot IDs		Q96KN1	P06132
PDB IDs			1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Integrin-mediated Signaling Pathway Cellular Response To Indole-3-methanol Gap Junction Assembly Protoporphyrinogen IX Biosynthetic Process Negative Regulation Of Neuroblast Proliferation Protoporphyrinogen IX Metabolic Process Epithelial Cell-cell Adhesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Stem Cell Proliferation Regulation Of Integrin-mediated Signaling Pathway Axon Regeneration Heme Biosynthetic Process Positive Regulation Of Smoothened Signaling Pathway Neuron Projection Regeneration Negative Regulation Of Neural Precursor Cell Proliferation Porphyrin-containing Compound Biosynthetic Process Regulation Of Neuroblast Proliferation Heme Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Porphyrin-containing Compound Metabolic Process Response To Axon Injury Ovarian Follicle Development Apical Junction Assembly Pigment Biosynthetic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Smoothened Signaling Pathway Tetrapyrrole Metabolic Process Ovulation Cycle Process Positive Regulation Of Muscle Cell Differentiation Adherens Junction Organization Odontogenesis Of Dentin-containing Tooth Regulation Of Neural Precursor Cell Proliferation Female Gonad Development Ovulation Cycle Regulation Of Stem Cell Proliferation Development Of Primary Female Sexual Characteristics Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Odontogenesis Protein Heterooligomerization Male Gonad Development Regulation Of Muscle Cell Differentiation	Astrocyte Development Astrocyte Differentiation Glial Cell Development Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Protein Import Into Nucleus Glial Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Activation Of Phospholipase A2 Activity Negative Regulation Of Signal Transduction Positive Regulation Of Phospholipase A2 Activity Gliogenesis Negative Regulation Of Signaling Response To Cobalamin Response To UV-A Regulation Of Intracellular Protein Transport Cytoplasmic Sequestering Of NF-kappaB Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Bergmann Glial Cell Differentiation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Regulation Of Protein Catabolic Process Regulation Of Superoxide Anion Generation Magnesium Ion Homeostasis Regulation Of Metabolic Process Regulation Of Intracellular Transport Intermediate Filament Organization Negative Regulation Of NF-kappaB Import Into Nucleus Cellular Response To Estradiol Stimulus Lens Fiber Cell Development Protein Insertion Into Membrane Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Catenin Import Into Nucleus Cellular Response To Epidermal Growth Factor Stimulus Cytoplasmic Sequestering Of Protein
Tagcloud ?		11q22 18p11 18q21 1p11 1p31 250k 2q22 3p11 3p12 3q11 4q22 5p15 8p23 birc2 bnip3l casp6 cnat cth ctnnd2 diras3 epha3 fgf19 fgf3 fgf4 gistic lrp1b mina myeov yes1	affinities arg37 arg41 arg803 asp863 attempts backbone candidates catalytic cmu computational decarboxylase edu egfr evolving head her2 http modulate neck radiotherapy residues taiwan tcm thr854 thr862 traditional tw uroporphyrinogen
Tagcloud (Difference) ?		11q22 18p11 18q21 1p11 1p31 250k 2q22 3p11 3p12 3q11 4q22 5p15 8p23 birc2 bnip3l casp6 cnat cth ctnnd2 diras3 epha3 fgf19 fgf3 fgf4 gistic lrp1b mina myeov yes1	affinities arg37 arg41 arg803 asp863 attempts backbone candidates catalytic cmu computational decarboxylase edu egfr evolving head her2 http modulate neck radiotherapy residues taiwan tcm thr854 thr862 traditional tw uroporphyrinogen
Tagcloud (Intersection) ?