FAM84B and CTNNA1

Number of citations of the paper that reports this interaction (PMID 12477722)
31

Data Source:
HPRD (two hybrid)

		FAM84B	CTNNA1
Gene Name		family with sequence similarity 84, member B	catenin (cadherin-associated protein), alpha 1, 102kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Lamellipodium
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Poly(A) RNA Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process		Ovarian Follicle Development Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Cell Junction Assembly Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Muscle Cell Differentiation Apical Junction Assembly Response To Estrogen Cell-cell Junction Organization Positive Regulation Of Smoothened Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Cell junction organization Cell-cell junction organization CDO in myogenesis Myogenesis Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: CTNNA1 UROD	27 interactors: ACTN1 AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CTBP1 CTNNB1 DLG1 FAM84B JUP MLLT4 PKD1 PSEN1 RNF219 SPTAN1 SPTBN1 SUMO1 TJP1 TJP2 VCL ZGPAT
Entrez ID		157638	1495
HPRD ID		11403	00285
Ensembl ID		ENSG00000168672	ENSG00000044115
Uniprot IDs		Q96KN1	P35221
PDB IDs			1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Integrin-mediated Signaling Pathway Cellular Response To Indole-3-methanol Gap Junction Assembly Protoporphyrinogen IX Biosynthetic Process Negative Regulation Of Neuroblast Proliferation Protoporphyrinogen IX Metabolic Process Epithelial Cell-cell Adhesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Stem Cell Proliferation Regulation Of Integrin-mediated Signaling Pathway Axon Regeneration Heme Biosynthetic Process Positive Regulation Of Smoothened Signaling Pathway Neuron Projection Regeneration Negative Regulation Of Neural Precursor Cell Proliferation Porphyrin-containing Compound Biosynthetic Process Regulation Of Neuroblast Proliferation Heme Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Porphyrin-containing Compound Metabolic Process Response To Axon Injury Ovarian Follicle Development Apical Junction Assembly Pigment Biosynthetic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Smoothened Signaling Pathway Tetrapyrrole Metabolic Process Ovulation Cycle Process Positive Regulation Of Muscle Cell Differentiation Adherens Junction Organization Odontogenesis Of Dentin-containing Tooth Regulation Of Neural Precursor Cell Proliferation Female Gonad Development Ovulation Cycle Regulation Of Stem Cell Proliferation Development Of Primary Female Sexual Characteristics Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Odontogenesis Protein Heterooligomerization Male Gonad Development Regulation Of Muscle Cell Differentiation	Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Cell Adhesion Cellular Component Assembly Epithelium Development Developmental Process Anatomical Structure Development Cell-cell Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Execution Phase Of Apoptosis Adherens Junction Assembly Cell Differentiation Tissue Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Development Cellular Response To Indole-3-methanol Establishment Of Endothelial Barrier Apical Junction Assembly Anatomical Structure Morphogenesis Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Complex Assembly Regulation Of Cellular Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Skin Development Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Endothelial Cell Development Tight Junction Assembly Positive Regulation Of Protein Metabolic Process Locomotion Endomembrane System Organization Neurogenesis Apoptotic Process Regulation Of Epithelial Cell Proliferation Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Programmed Cell Death Morphogenesis Of An Epithelium Cell Death Death Cell-matrix Adhesion Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Endothelial Cell Differentiation Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization
Tagcloud ?		11q22 18p11 18q21 1p11 1p31 250k 2q22 3p11 3p12 3q11 4q22 5p15 8p23 birc2 bnip3l casp6 cnat cth ctnnd2 diras3 epha3 fgf19 fgf3 fgf4 gistic lrp1b mina myeov yes1	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Difference) ?		11q22 18p11 18q21 1p11 1p31 250k 2q22 3p11 3p12 3q11 4q22 5p15 8p23 birc2 bnip3l casp6 cnat cth ctnnd2 diras3 epha3 fgf19 fgf3 fgf4 gistic lrp1b mina myeov yes1	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Intersection) ?