AMOT and AXIN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AMOT	AXIN2
Description		angiomotin	axin 2
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GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Lamellipodium Endocytic Vesicle Cytoplasmic Vesicle Anchoring Junction Glutamatergic Synapse	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Beta-catenin Destruction Complex Protein-containing Complex
	Molecular Function	Protein Binding Signaling Receptor Activity Angiostatin Binding	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Molecular Adaptor Activity I-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Cell-cell Junction Assembly Intracellular Protein Localization Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Negative Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Size Blood Vessel Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Regulation Of Modification Of Postsynaptic Actin Cytoskeleton	Osteoblast Differentiation Somitogenesis Intramembranous Ossification Secondary Heart Field Specification Aortic Valve Morphogenesis Mitral Valve Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Odontogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of DNA Repeat Elements Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Cell Development Response To Steroid Hormone Canonical Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization
Pathways			TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases			Oligodontia-colorectal cancer syndrome Tooth agenesis; Hypodontia
GWAS			Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		58 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NTAQ1 NUFIP2 PBLD PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UBC UNC119 YAP1	56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SIAH1 SMAD1 SMAD3 SMAD7 SNCA STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648
Entrez ID		154796	8313
HPRD ID		02327	04935
Ensembl ID		ENSG00000126016	ENSG00000168646
Uniprot IDs		Q4VCS5	B7ZKL5 E7ES00 Q9Y2T1
PDB IDs		6JJX 7LP2 7LP3 7LP5 7NMA 7NMW 7NMX 7NN2 7NND 7NNE 7NP2 7NPB 7NPG 7OQG 7OQJ 7OQS 7OQU 7OQW	8HEO
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Organelle Organization Anatomical Structure Morphogenesis Sarcomere Organization Structural Constituent Of Cytoskeleton Epithelial Cell Differentiation Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Muscle Developmental Process Cytosol M Band Extracellular Exosome Actomyosin Structure Organization Tissue Development Cellular Developmental Process Epidermis Development Protein Binding Actin Cytoskeleton Organization Phosphothreonine Residue Binding Cornified Envelope Cell Differentiation Actin Filament-based Process Response To Calcium Ion Positive Regulation Of Catabolic Process Response To Radiation Response To Metal Ion Skeletal Muscle Thin Filament Assembly Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Reproductive Behavior Regulation Of Caveolin-mediated Endocytosis Cytoskeleton Cellular Response To Metal Ion Sodium Channel Inhibitor Activity Positive Regulation Of Protein Metabolic Process Striated Muscle Thin Filament Outer Ear Morphogenesis Cellular Response To Salt Stress Potassium Channel Inhibitor Activity Regulation Of Cell Motility Identical Protein Binding	Beta-catenin Destruction Complex Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Binding Regulation Of Wnt Signaling Pathway I-SMAD Binding Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Organization Heteromeric SMAD Protein Complex Regulation Of Cartilage Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signalosome Centrosome Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Ureteric Bud Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleus Cell Junction Organization Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Mesonephric Epithelium Development Mesonephric Tubule Development Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process SMAD Protein Signal Transduction Positive Regulation Of Catabolic Process Response To Growth Factor Regulation Of Long-term Neuronal Synaptic Plasticity Kidney Epithelium Development Catenin Complex Regulation Of Intracellular Protein Transport Regulation Of Osteoblast Differentiation Identical Protein Binding Protein Binding Positive Regulation Of Cartilage Development Regulation Of Protein Localization To Nucleus Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome SMAD Protein Complex Regulation Of Protein Export From Nucleus
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