AMOT and PPP2R4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AMOT	PPP2R4
Gene Name		angiomotin	protein phosphatase 2A activator, regulatory subunit 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Tight Junction COP9 Signalosome External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Lamellipodium Endocytic Vesicle	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Protein Binding Angiostatin Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Receptor Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Type 2A Regulator Activity ATPase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Protein Phosphatase 2A Binding
	Biological Process	Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Cell-cell Junction Assembly Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Negative Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Size Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly	Protein Peptidyl-prolyl Isomerization Metabolic Process Mitotic Spindle Organization In Nucleus Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Drugs
Diseases
GWAS			Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Protein-Protein Interactions		21 interactors: ACTA1 APP C1orf216 KRT15 KRT31 LATS1 LATS2 LMO4 LURAP1 MAGEA4 MAGI1 MAPK3 MED4 NEDD4 PIN1 PLG PPP2R4 SEPT1 SNAPC5 UNC119 WDYHV1	19 interactors: AKT1 AMOT APP AURKB BCL2 CCNG1 CCNG2 CSNK2A1 CYLD EIF4EBP1 H2AFX HDAC4 MAPT MID1 PIM1 PPP2R3A PRKCB RACGAP1 SRC
Entrez ID		154796	5524
HPRD ID		02327	02858
Ensembl ID		ENSG00000126016	ENSG00000119383
Uniprot IDs		Q4VCS5	B4DZF8 Q15257
PDB IDs			2G62 2HV6 2HV7 2IXM
Enriched GO Terms of Interacting Partners?		Tissue Development Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Epidermis Development Cell Cycle Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Hippo Signaling Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Phosphorylation Cell Division Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Platelet Activation Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Mitotic Spindle Organization In Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Apolipoprotein Binding Transmission Of Virus Development Involved In Symbiotic Interaction Neuromuscular Junction Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Neuron Death Regulation Of Sodium Ion Transport Epithelium Development Negative Regulation Of Signal Transduction Protein Peptidyl-prolyl Isomerization Platelet Degranulation Response To Abiotic Stimulus Intracellular Steroid Hormone Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Caveolin-mediated Endocytosis Organ Development	Regulation Of Cell Cycle Cell Cycle Regulation Of Organelle Organization Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Cell Death Death Regulation Of Cellular Component Organization Organelle Organization Multicellular Organismal Development Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Microtubule-based Process Apoptotic Process Developmental Process Regulation Of Signaling Cellular Response To Stimulus Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle Checkpoint Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Binding Response To Stress Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Nervous System Development Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Cell Growth Negative Regulation Of Mitochondrial Depolarization Regulation Of Growth Negative Regulation Of Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process
Tagcloud ?		actin alanine amotl2 amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Difference) ?		actin alanine amotl2 amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Intersection) ?