AMOT and YAP1

Number of citations of the paper that reports this interaction (PubMedID 33477952)
64

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology, proximity labelling technology, fluorescent resonance energy transfer)

		AMOT	YAP1
Description		angiomotin	Yes1 associated transcriptional regulator
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GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Lamellipodium Endocytic Vesicle Cytoplasmic Vesicle Anchoring Junction Glutamatergic Synapse	Female Germ Cell Nucleus Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction TEAD-YAP Complex
	Molecular Function	Protein Binding Signaling Receptor Activity Angiostatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Cell-cell Junction Assembly Intracellular Protein Localization Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Negative Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Size Blood Vessel Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Regulation Of Modification Of Postsynaptic Actin Cytoskeleton	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Blastocyst Development Trophectodermal Cell Differentiation Tissue Homeostasis Glandular Epithelial Cell Differentiation Heart Process Embryonic Heart Tube Morphogenesis DNA Damage Response Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Positive Regulation Of Cell Growth Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Polarized Epithelial Cell Differentiation Notochord Development Response To Progesterone Somatic Stem Cell Population Maintenance Organ Growth Hippo Signaling Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Intestinal Epithelial Cell Development Regulation Of Canonical Wnt Signaling Pathway Cardiac Muscle Tissue Regeneration Canonical Glycolysis Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Positive Regulation Of Stem Cell Population Maintenance Enterocyte Differentiation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of axial mesoderm Zygotic genome activation (ZGA) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases
GWAS			Cleft palate ( 27018472) Colorectal cancer or advanced adenoma ( 30510241) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Migraine ( 27322543) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 22885925 26416764 30566500) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Pulse pressure ( 30224653 30578418) Reticulocyte count ( 32888494) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		58 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NTAQ1 NUFIP2 PBLD PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UBC UNC119 YAP1	103 interacting genes: ABL1 AKT1 AMOT ANK3 APC2 ARID2 ATN1 BEAN1 CCDC87 CDIP1 CNKSR2 CRTC3 CSNK1D CSNK1E DDN EIF3H ENAH ENTREP3 ERBB4 ESS2 FBXW7 FOXI1 FOXJ3 FXR1 GAB1 GAS5 GBF1 GLIS3 HNRNPU HNRNPUL1 IGSF9B JCAD JOSD2 KIF5A LATS2 LINC00839 MAP2 MAP3K2 MAP3K3 MAPKAPK5 MLANA MRPL49 MYCT1 NDFIP2 NEK1 NFE2 NHERF1 NR1I2 OTUB1 OTUD1 PIP4P1 PIP4P2 PKNOX2 PRR7 PRRG2 PRRG4 PTCH1 PTEN PTPN21 RBM14 RHBDD2 RNF11 RNF38 RUNX1 RUNX2 RUNX3 SCAMP3 SCAMP4 SCN1A SDCBP SH3D21 SHISA4 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TGFB1I1 TMEM139 TMEM151B TMEM252 TMEM59L TMEM61 TMEM92 TNRC18 TP53BP2 TP63 TP73 TRERF1 TRIP6 TSPYL2 TTYH3 UBE2L6 UCHL3 UVRAG WBP1 WBP2 WT1 YWHAG YWHAQ YWHAZ
Entrez ID		154796	10413
HPRD ID		02327	09424
Ensembl ID		ENSG00000126016	ENSG00000137693
Uniprot IDs		Q4VCS5	K0KVU2 P46937
PDB IDs		6JJX 7LP2 7LP3 7LP5 7NMA 7NMW 7NMX 7NN2 7NND 7NNE 7NP2 7NPB 7NPG 7OQG 7OQJ 7OQS 7OQU 7OQW	1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X 7O07 8A8Q 8A8R 8C2F 8WRG 9FZA
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Organelle Organization Anatomical Structure Morphogenesis Sarcomere Organization Structural Constituent Of Cytoskeleton Epithelial Cell Differentiation Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Muscle Developmental Process Cytosol M Band Extracellular Exosome Actomyosin Structure Organization Tissue Development Cellular Developmental Process Epidermis Development Protein Binding Actin Cytoskeleton Organization Phosphothreonine Residue Binding Cornified Envelope Cell Differentiation Actin Filament-based Process Response To Calcium Ion Positive Regulation Of Catabolic Process Response To Radiation Response To Metal Ion Skeletal Muscle Thin Filament Assembly Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Reproductive Behavior Regulation Of Caveolin-mediated Endocytosis Cytoskeleton Cellular Response To Metal Ion Sodium Channel Inhibitor Activity Positive Regulation Of Protein Metabolic Process Striated Muscle Thin Filament Outer Ear Morphogenesis Cellular Response To Salt Stress Potassium Channel Inhibitor Activity Regulation Of Cell Motility Identical Protein Binding	WW Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Organ Growth Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of Developmental Growth Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cell Fate Commitment Positive Regulation Of Intracellular Signal Transduction Regulation Of Growth Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Chromatin Positive Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Gene Expression Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Communication Protein Phosphorylation Regulation Of Mitotic Cell Cycle Embryonic Organ Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Protein Domain Specific Binding Golgi Localization
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