AMOT and PIK3C2A

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		AMOT	PIK3C2A
Description		angiomotin	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Lamellipodium Endocytic Vesicle Cytoplasmic Vesicle Anchoring Junction Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity Angiostatin Binding	Nucleotide Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity Clathrin Binding 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Cell-cell Junction Assembly Intracellular Protein Localization Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Negative Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Size Blood Vessel Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Regulation Of Modification Of Postsynaptic Actin Cytoskeleton	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Exocytosis Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Vascular Associated Smooth Muscle Contraction Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Clathrin Coat Assembly Membrane Organization Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways			Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Body mass index ( 26426971) Platelet count ( 32888494) Schizophrenia or bipolar disorder ( 24280982) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		58 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NTAQ1 NUFIP2 PBLD PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UBC UNC119 YAP1	3 interacting genes: AMOT EGFR ERBB2
Entrez ID		154796	5286
HPRD ID		02327	04672
Ensembl ID		ENSG00000126016	ENSG00000011405
Uniprot IDs		Q4VCS5	B4DG55 L7RRS0 O00443
PDB IDs		6JJX 7LP2 7LP3 7LP5 7NMA 7NMW 7NMX 7NN2 7NND 7NNE 7NP2 7NPB 7NPG 7OQG 7OQJ 7OQS 7OQU 7OQW	2AR5 2IWL 2REA 2RED 6BTY 6BTZ 6BU0 6BUB
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Organelle Organization Anatomical Structure Morphogenesis Sarcomere Organization Structural Constituent Of Cytoskeleton Epithelial Cell Differentiation Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Muscle Developmental Process Cytosol M Band Extracellular Exosome Actomyosin Structure Organization Tissue Development Cellular Developmental Process Epidermis Development Protein Binding Actin Cytoskeleton Organization Phosphothreonine Residue Binding Cornified Envelope Cell Differentiation Actin Filament-based Process Response To Calcium Ion Positive Regulation Of Catabolic Process Response To Radiation Response To Metal Ion Skeletal Muscle Thin Filament Assembly Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Reproductive Behavior Regulation Of Caveolin-mediated Endocytosis Cytoskeleton Cellular Response To Metal Ion Sodium Channel Inhibitor Activity Positive Regulation Of Protein Metabolic Process Striated Muscle Thin Filament Outer Ear Morphogenesis Cellular Response To Salt Stress Potassium Channel Inhibitor Activity Regulation Of Cell Motility Identical Protein Binding	ERBB2-EGFR Signaling Pathway ERBB2 Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Basal Plasma Membrane Endocytic Vesicle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ruffle Membrane Negative Regulation Of Developmental Process Protein Tyrosine Kinase Activity Multivesicular Body, Internal Vesicle Lumen Positive Regulation Of Cell Growth Shc-EGFR Complex Negative Regulation Of Multicellular Organismal Process ERBB3:ERBB2 Complex Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Transmembrane Signaling Receptor Activity Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Positive Regulation Of Protein Phosphorylation RNA Polymerase I Core Binding Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase C Signaling Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Growth Epidermal Growth Factor Binding Endosome Membrane Basolateral Plasma Membrane Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Angiostatin Binding Tube Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Angiogenesis Negative Regulation Of Immature T Cell Proliferation Intracellular Signal Transduction Regulation Of Vasculature Development Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Neuron Differentiation Regulation Of Epithelial Cell Proliferation
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