CATSPERT and ACTN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CATSPERT	ACTN3
Description		catsper channel auxiliary subunit tau	actinin alpha 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Motile Cilium CatSper Complex Cell Projection Sperm Principal Piece	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Spermatogenesis Flagellated Sperm Motility Sperm Capacitation Vesicle-mediated Transport To The Plasma Membrane	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways			Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		62 interacting genes: ACOT11 ACTN3 ANKK1 AP2B1 BBS4 BRCA1 CARD9 CCDC172 CCDC57 CCDC85B CDR2 CHCHD3 CNOT11 CT55 DISC1 DNAJA3 FAM217B FHL2 GOLGA2 GPRASP3 GRAMD4 HAP1 HSF2BP HSPB8 IKZF3 JRK KIFC3 KRT13 KRT15 KRT31 KRT40 KRT75 LHX1 LHX3 LZTS2 MCM6 MCRS1 MEAF6 MEOX1 MIPOL1 MTUS2 NR5A1 NUTM1 PAX6 PIBF1 RNF8 SPATA2 TACC3 TCP10L TEX11 TFIP11 TLE5 TRAF1 TRAF2 TRIM23 TRIM54 TSSK3 VAC14 VIM VPS52 ZNF474 ZNRD2	61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426
Entrez ID		151254	89
HPRD ID		08687	02148
Ensembl ID		ENSG00000155754	ENSG00000248746
Uniprot IDs		A0A140VJE2 Q53TS8	A0A087WSZ2 B4DZQ2 Q08043
PDB IDs			1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Identical Protein Binding Cytoskeleton Structural Constituent Of Skin Epidermis Protein Binding Centrosome Intermediate Filament Keratin Filament Microtubule-based Process Organelle Organization Cytoplasm Protein Localization To Centrosome Centriolar Satellite Cell Differentiation Regulation Of Programmed Cell Death Microtubule Cytoskeleton Organization Microtubule Organizing Center Organization Ureter Morphogenesis Developmental Process Ventral Spinal Cord Development Cellular Developmental Process Transcription Coregulator Binding Structural Molecule Activity Regulation Of Apoptotic Process Thioesterase Binding Epithelial Cell Differentiation Spinal Cord Association Neuron Differentiation Protein Localization To Cytoskeleton Centrosome Cycle Intermediate Filament Cytoskeleton Regulation Of Non-motile Cilium Assembly HMG Box Domain Binding Non-motile Cilium Assembly	Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding
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