VCAM1 and MSN

Number of citations of the paper that reports this interaction (PMID 12082081)
93

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		VCAM1	MSN
Gene Name		vascular cell adhesion molecule 1	moesin
Image
Gene Ontology Annotations	Cellular Component	Podosome Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Filopodium Sarcolemma Apical Part Of Cell Extracellular Vesicular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex	Uropod Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Microvillus Focal Adhesion Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium Microvillus Membrane Vesicle Apical Part Of Cell Extracellular Vesicular Exosome Cell Periphery Blood Microparticle
	Molecular Function	Integrin Binding Primary Amine Oxidase Activity Cell Adhesion Molecule Binding	Double-stranded RNA Binding Actin Binding Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	Response To Hypoxia Acute Inflammatory Response Chronic Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Heart Development Aging Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Viral Process Cytokine-mediated Signaling Pathway Membrane To Membrane Docking B Cell Differentiation Extracellular Matrix Organization Response To Lipopolysaccharide Response To Nicotine Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Regulation Of Immune Response Leukocyte Tethering Or Rolling Oxidation-reduction Process Cell Chemotaxis Interferon-gamma-mediated Signaling Pathway Chorio-allantoic Fusion Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor	Movement Of Cell Or Subcellular Component Leukocyte Cell-cell Adhesion Positive Regulation Of Gene Expression Membrane To Membrane Docking Leukocyte Migration Establishment Of Endothelial Barrier Regulation Of Lymphocyte Migration
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Axon guidance L1CAM interactions Recycling pathway of L1
Drugs		Carvedilol
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		10 interactors: CCL17 CCL22 CTSG ELANE EZR IL13 ITGAD ITGB1 ITGB7 MSN	24 interactors: BCAP31 CD44 CD46 CD93 CDK11B EZR ICAM1 ICAM2 ICAM3 L1CAM NCF1 NCF4 PLEC PPM1A PPM1B PRKCQ ROCK1 SELL SELPLG SLC9A3R1 SPN TERF1 TSC1 VCAM1
Entrez ID		7412	4478
HPRD ID		01888	02399
Ensembl ID		ENSG00000162692	ENSG00000147065
Uniprot IDs		P19320	P26038
PDB IDs		1IJ9 1VCA 1VSC	1E5W 1EF1 1SGH
Enriched GO Terms of Interacting Partners?		Immune System Process Movement Of Cell Or Subcellular Component Response To External Stimulus Heterotypic Cell-cell Adhesion Leukocyte Cell-cell Adhesion Locomotion Response To Other Organism Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Membrane To Membrane Docking Leukocyte Migration Killing By Host Of Symbiont Cells Immune Response Regulation Of Immune System Process Defense Response Integrin-mediated Signaling Pathway Leukocyte Tethering Or Rolling Inflammatory Response Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Cell Adhesion Establishment Of Endothelial Barrier Cellular Extravasation Chemotaxis Interaction With Symbiont Leukocyte Mediated Cytotoxicity Response To Fungus Viral Entry Into Host Cell Entry Into Host Cell Response To Virus Endothelial Cell Development Response To Lipopolysaccharide Positive Regulation Of Smooth Muscle Cell Proliferation Response To Lipid Response To Molecule Of Bacterial Origin Regulation Of Immune Response Cellular Response To Mechanical Stimulus Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Endothelial Cell Differentiation Response To Stimulus	Membrane To Membrane Docking Single Organismal Cell-cell Adhesion Cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Positive Regulation Of Cell Adhesion Immune System Process Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Cellular Extravasation Membrane Docking Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Cell-cell Adhesion Locomotion Regulation Of Immune System Process Regulation Of T Cell Proliferation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Movement Of Cell Or Subcellular Component Execution Phase Of Apoptosis Cell Migration Regulation Of Cell-cell Adhesion Cell Motility Positive Regulation Of T Cell Activation Cell Surface Receptor Signaling Pathway Immune Response Apoptotic Process Blood Coagulation Inflammatory Response Hemostasis Cell Activation Programmed Cell Death Cell Death Death Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Signal Transduction Leukocyte Activation Interferon-gamma-mediated Signaling Pathway Response To Stimulus Regulation Of T Cell Activation Innate Immune Response Positive Regulation Of Cell Activation Negative Regulation Of Signaling Cellular Response To Interferon-gamma Regulation Of Body Fluid Levels
Tagcloud ?		accessory cd4 delayed determinant dr foreign genital hpvs hypersensitivity icam1 immuno keratinocytes langerhans lymphocytes monitored mount nonregressing papillomavirus predominated rank regressing regression responsiveness selectin stroma sum wart warts wilcoxon	assignments cen discordancy est00675 est00745 est00795 est00887 est00896 est01041 est01471 est01583 est01627 est01650 est01678 est01744 ests globule l18a l1a l1b moesin multiplexed s14 subregionally sulfurtransferase thiosulfate transhydrogenase xp11 xpter
Tagcloud (Difference) ?		accessory cd4 delayed determinant dr foreign genital hpvs hypersensitivity icam1 immuno keratinocytes langerhans lymphocytes monitored mount nonregressing papillomavirus predominated rank regressing regression responsiveness selectin stroma sum wart warts wilcoxon	assignments cen discordancy est00675 est00745 est00795 est00887 est00896 est01041 est01471 est01583 est01627 est01650 est01678 est01744 ests globule l18a l1a l1b moesin multiplexed s14 subregionally sulfurtransferase thiosulfate transhydrogenase xp11 xpter
Tagcloud (Intersection) ?