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VCAM1 and ELANE
Number of citations of the paper that reports this interaction (PubMedID
11520773
)
0
Data Source:
HPRD
(in vitro)
VCAM1
ELANE
Description
vascular cell adhesion molecule 1
elastase, neutrophil expressed
Image
GO Annotations
Cellular Component
Podosome
Extracellular Region
Extracellular Space
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Microvillus
External Side Of Plasma Membrane
Cell Surface
Membrane
Filopodium
Sarcolemma
Apical Part Of Cell
Extracellular Exosome
Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
Extracellular Region
Extracellular Space
Cytoplasm
Golgi Apparatus
Cytosol
Cell Surface
Transcription Repressor Complex
Secretory Granule
Extracellular Matrix
Cytoplasmic Vesicle
Azurophil Granule Lumen
Specific Granule Lumen
Phagocytic Vesicle
Extracellular Exosome
Molecular Function
Integrin Binding
Primary Methylamine Oxidase Activity
Cell Adhesion Molecule Binding
Cell Adhesion Mediator Activity
Protease Binding
Transcription Corepressor Activity
Endopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Heparin Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Cytokine Binding
Biological Process
Response To Hypoxia
Chronic Inflammatory Response
Inflammatory Response
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Response To Nutrient
Amine Metabolic Process
Response To Zinc Ion
Response To Ionizing Radiation
Membrane To Membrane Docking
B Cell Differentiation
Response To Lipopolysaccharide
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Response To Nicotine
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of T Cell Proliferation
Response To Ethanol
Leukocyte Tethering Or Rolling
Cell Chemotaxis
Innervation
Cardiac Neuron Differentiation
Cellular Response To Tumor Necrosis Factor
Cell-cell Adhesion
Cellular Response To Amyloid-beta
Negative Regulation Of Transcription By RNA Polymerase II
Response To Yeast
Acute Inflammatory Response To Antigenic Stimulus
Leukocyte Migration Involved In Inflammatory Response
Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria
Proteolysis
Intracellular Calcium Ion Homeostasis
Phagocytosis
Response To UV
Extracellular Matrix Disassembly
Protein Catabolic Process
Response To Lipopolysaccharide
Negative Regulation Of Chemokine Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Interleukin-8 Production
Defense Response To Bacterium
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Immune Response
Defense Response To Fungus
Leukocyte Migration
Negative Regulation Of Chemotaxis
Pyroptotic Inflammatory Response
Neutrophil-mediated Killing Of Gram-negative Bacterium
Neutrophil-mediated Killing Of Fungus
Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Pyroptosis
Neutrophil degranulation
Antimicrobial peptides
Regulation of Complement cascade
Expression of NOTCH2NL genes
Drugs
Ethanol
Carvedilol
Succinobucol
Clove oil
Alpha-1-proteinase inhibitor
Mdl 101,146
Freselestat
Elafin
Lupeol
Ursolic acid
Diseases
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Multiple sclerosis (
21833088
24076602
31604244
)
Neutrophil percentage of white cells (
32888494
)
Sjögren's syndrome (
24097067
)
Blood protein levels (
30072576
)
Interacting Genes
13 interacting genes:
CCL17
CCL22
CTSG
ELANE
EZR
IL13
ITGAD
ITGB1
ITGB7
MSN
TRIM54
TRIM65
USP2
31 interacting genes:
ACE2
CAMP
CSF3
CSF3R
CXCL12
CXCR4
ELN
F2R
F2RL1
F5
GRN
ITGAM
KNG1
LPA
LRP1
NOTCH2NLA
SDC1
SERPINA1
SERPINA3
SERPINB1
SERPINB13
SERPIND1
SERPINE1
SERPINF2
SERPING1
SLPI
TFPI
TGFA
THBS1
VCAM1
YARS1
Entrez ID
7412
1991
HPRD ID
01888
00554
Ensembl ID
ENSG00000162692
ENSG00000197561
Uniprot IDs
P19320
P08246
PDB IDs
1IJ9
1VCA
1VSC
1B0F
1H1B
1HNE
1PPF
1PPG
2RG3
2Z7F
3Q76
3Q77
4NZL
4WVP
5A09
5A0A
5A0B
5A0C
5A8X
5A8Y
5A8Z
5ABW
6E69
6F5M
6SMA
7CBK
7WHU
8D4Q
8D4U
8D7I
8D7K
8G24
8G25
8G26
8QGX
8VK5
9ASS
9ASX
9ATK
9ATU
Enriched GO Terms of Interacting Partners
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Immune System Process
Immune Response
Leukocyte Cell-cell Adhesion
Leukocyte Migration
Cell Adhesion Molecule Binding
Integrin Complex
Killing Of Cells Of Another Organism
Inflammatory Response
Heterotypic Cell-cell Adhesion
Cell Migration
Defense Response
Membrane To Membrane Docking
Cell Motility
Response To Other Organism
Cell Killing
Defense Response To Symbiont
Positive Regulation Of Early Endosome To Late Endosome Transport
Defense Response To Other Organism
Positive Regulation Of Protein Localization To Early Endosome
Neutrophil-mediated Killing Of Bacterium
Filopodium
Cell-cell Adhesion
Positive Regulation Of Protein Localization To Endosome
Response To External Biotic Stimulus
Uropod
Integrin-mediated Signaling Pathway
Cell-matrix Adhesion
Establishment Of Epithelial Cell Apical/basal Polarity
Mononuclear Cell Migration
Regulation Of Early Endosome To Late Endosome Transport
Extracellular Space
Leukocyte Tethering Or Rolling
Neutrophil Mediated Immunity
Cell Surface
Establishment Of Apical/basal Cell Polarity
Leukocyte Adhesion To Vascular Endothelial Cell
Polarized Epithelial Cell Differentiation
Establishment Of Monopolar Cell Polarity
Establishment Or Maintenance Of Monopolar Cell Polarity
Cell Adhesion Mediated By Integrin
Microvillus Membrane
Gland Morphogenesis
Establishment Of Epithelial Cell Polarity
Cell-substrate Adhesion
Antimicrobial Humoral Response
Killing By Host Of Symbiont Cells
Cytokine-mediated Signaling Pathway
Focal Adhesion
T Cell Migration
Biological Process Involved In Interaction With Symbiont
Extracellular Region
Peptidase Inhibitor Activity
Extracellular Space
Serine-type Endopeptidase Inhibitor Activity
Endopeptidase Inhibitor Activity
Platelet Alpha Granule Lumen
Regulation Of Blood Coagulation
Regulation Of Hemostasis
Regulation Of Body Fluid Levels
Circulatory System Process
Blood Coagulation
Coagulation
Hemostasis
Regulation Of Response To Wounding
Extracellular Exosome
Extracellular Matrix
Regulation Of Wound Healing
Defense Response
Blood Circulation
Inflammatory Response
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Protease Binding
Regulation Of Biological Quality
Cell Surface
Positive Regulation Of Blood Coagulation
Negative Regulation Of Wound Healing
Negative Regulation Of Proteolysis
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Coagulation
Regulation Of Multicellular Organismal Process
Chronic Inflammatory Response
Endoplasmic Reticulum Lumen
Positive Regulation Of Vasculature Development
Regulation Of Systemic Arterial Blood Pressure
Negative Regulation Of Fibrinolysis
Immune System Process
External Side Of Plasma Membrane
Positive Regulation Of Cell Population Proliferation
Regulation Of Fibrinolysis
Regulation Of Plasminogen Activation
Regulation Of Proteolysis
System Process
Positive Regulation Of Interleukin-8 Production
Fibrinolysis
Signaling Receptor Binding
Positive Regulation Of Wound Healing
Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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