VCAM1 and CCL17

Number of citations of the paper that reports this interaction (PMID 12193695)
6

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		VCAM1	CCL17
Gene Name		vascular cell adhesion molecule 1	chemokine (C-C motif) ligand 17
Image
Gene Ontology Annotations	Cellular Component	Podosome Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Filopodium Sarcolemma Apical Part Of Cell Extracellular Vesicular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex	Extracellular Region Extracellular Space
	Molecular Function	Integrin Binding Primary Amine Oxidase Activity Cell Adhesion Molecule Binding	Receptor Binding Chemokine Activity CCR4 Chemokine Receptor Binding
	Biological Process	Response To Hypoxia Acute Inflammatory Response Chronic Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Heart Development Aging Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Viral Process Cytokine-mediated Signaling Pathway Membrane To Membrane Docking B Cell Differentiation Extracellular Matrix Organization Response To Lipopolysaccharide Response To Nicotine Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Regulation Of Immune Response Leukocyte Tethering Or Rolling Oxidation-reduction Process Cell Chemotaxis Interferon-gamma-mediated Signaling Pathway Chorio-allantoic Fusion Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor	Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Negative Regulation Of Myoblast Differentiation Cell Chemotaxis
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Carvedilol
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		10 interactors: CCL17 CCL22 CTSG ELANE EZR IL13 ITGAD ITGB1 ITGB7 MSN	4 interactors: ACKR1 CCR4 CCR8 VCAM1
Entrez ID		7412	6361
HPRD ID		01888	03309
Ensembl ID		ENSG00000162692	ENSG00000102970
Uniprot IDs		P19320	Q92583
PDB IDs		1IJ9 1VCA 1VSC	1NR2 1NR4
Enriched GO Terms of Interacting Partners?		Immune System Process Movement Of Cell Or Subcellular Component Response To External Stimulus Heterotypic Cell-cell Adhesion Leukocyte Cell-cell Adhesion Locomotion Response To Other Organism Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Membrane To Membrane Docking Leukocyte Migration Killing By Host Of Symbiont Cells Immune Response Regulation Of Immune System Process Defense Response Integrin-mediated Signaling Pathway Leukocyte Tethering Or Rolling Inflammatory Response Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Cell Adhesion Establishment Of Endothelial Barrier Cellular Extravasation Chemotaxis Interaction With Symbiont Leukocyte Mediated Cytotoxicity Response To Fungus Viral Entry Into Host Cell Entry Into Host Cell Response To Virus Endothelial Cell Development Response To Lipopolysaccharide Positive Regulation Of Smooth Muscle Cell Proliferation Response To Lipid Response To Molecule Of Bacterial Origin Regulation Of Immune Response Cellular Response To Mechanical Stimulus Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Endothelial Cell Differentiation Response To Stimulus	Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Inflammatory Response Cellular Response To Organic Substance Cellular Chemical Homeostasis Chemotaxis Cellular Homeostasis Response To Organic Substance Chemical Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Cytosolic Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, No-go Decay Locomotion Immune Response Defense Response Homeostatic Process Membrane To Membrane Docking Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Cytoplasmic MRNA Processing Body Assembly Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Tolerance Induction Chorio-allantoic Fusion Cytoplasmic MRNA Processing Body Assembly Cellular Metal Ion Homeostasis Response To External Stimulus Cellular Cation Homeostasis Response To Radiation Cellular Ion Homeostasis Leukocyte Tethering Or Rolling Chronic Inflammatory Response Response To Extracellular Stimulus Metal Ion Homeostasis Response To Bacterium Signal Transduction Immune System Process Signaling Ion Homeostasis Cell Communication Labyrinthine Layer Morphogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Organelle Assembly
Tagcloud ?		accessory cd4 delayed determinant dr foreign genital hpvs hypersensitivity icam1 immuno keratinocytes langerhans lymphocytes monitored mount nonregressing papillomavirus predominated rank regressing regression responsiveness selectin stroma sum wart warts wilcoxon	addresses adoptive airway antiviral attributable bronchiolitis challenge challenged eosinophil eosinophilia eosinophilic eosinophils eotaxin fi formalin immunized inactivated inadequately lungs partly pulmonary recovered rsv syncytial tarc th2 titers vaccination wheezing
Tagcloud (Difference) ?		accessory cd4 delayed determinant dr foreign genital hpvs hypersensitivity icam1 immuno keratinocytes langerhans lymphocytes monitored mount nonregressing papillomavirus predominated rank regressing regression responsiveness selectin stroma sum wart warts wilcoxon	addresses adoptive airway antiviral attributable bronchiolitis challenge challenged eosinophil eosinophilia eosinophilic eosinophils eotaxin fi formalin immunized inactivated inadequately lungs partly pulmonary recovered rsv syncytial tarc th2 titers vaccination wheezing
Tagcloud (Intersection) ?