DUSP18 and MAPK8IP2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DUSP18	MAPK8IP2
Description		dual specificity phosphatase 18	mitogen-activated protein kinase 8 interacting protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding
	Biological Process	Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)
Interacting Genes		14 interacting genes: EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 IGF1R INSR MAPK8IP2 PTK7 ROR1 ROR2 TEK	86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784
Entrez ID		150290	23542
HPRD ID		13253	09674
Ensembl ID		ENSG00000167065	ENSG00000008735
Uniprot IDs		F2Z2P2 Q8NEJ0	Q13387
PDB IDs		2ESB	8RPP
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Kinase Activity ATP Binding Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of MAPK Cascade Ephrin Receptor Activity Transferase Activity Signal Transduction Positive Regulation Of MAPK Cascade Growth Factor Binding Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Coreceptor Activity Transmembrane-ephrin Receptor Activity Basal Plasma Membrane Regulation Of Intracellular Signal Transduction Plasma Membrane Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Organization Neuron Projection Guidance Axon Guidance ERBB3:ERBB2 Complex Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of Signal Transduction Heart Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuregulin Receptor Activity Insulin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Bounded Cell Projection Organization Insulin Receptor Complex Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Insulin Binding System Development	MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade
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