DUSP18

Description		dual specificity phosphatase 18
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 IGF1R INSR MAPK8IP2 PTK7 ROR1 ROR2 TEK
Entrez ID		150290
HPRD ID		13253
Ensembl ID		ENSG00000167065
Uniprot IDs		F2Z2P2 Q8NEJ0
PDB IDs		2ESB
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Kinase Activity ATP Binding Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of MAPK Cascade Ephrin Receptor Activity Transferase Activity Signal Transduction Positive Regulation Of MAPK Cascade Growth Factor Binding Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Coreceptor Activity Transmembrane-ephrin Receptor Activity Basal Plasma Membrane Regulation Of Intracellular Signal Transduction Plasma Membrane Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Organization Neuron Projection Guidance Axon Guidance ERBB3:ERBB2 Complex Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of Signal Transduction Heart Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuregulin Receptor Activity Insulin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Bounded Cell Projection Organization Insulin Receptor Complex Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Insulin Binding System Development
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