DUSP18 and EPHA7

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP18	EPHA7
Description		dual specificity phosphatase 18	EPH receptor A7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane	Plasma Membrane Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Growth Factor Binding Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation	Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Brain Development Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Negative Chemotaxis Neuron Apoptotic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Synapse Assembly Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Regulation Of Postsynapse Organization
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide Fostamatinib
Diseases
GWAS			Adult body size ( 32376654) Adventurousness ( 30643258) Anthropometric traits (multi-trait analysis) ( 30166351) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Chin dimples ( 27182965) Dialysis-related mortality ( 21546767) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Initial pursuit acceleration ( 29064472) Laryngeal squamous cell carcinoma ( 25194280) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to hepatitis C treatment ( 22095909) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		14 interacting genes: EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 IGF1R INSR MAPK8IP2 PTK7 ROR1 ROR2 TEK	12 interacting genes: AFDN DUSP18 DUSP26 EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MTMR14 STYX ZNF267
Entrez ID		150290	2045
HPRD ID		13253	03721
Ensembl ID		ENSG00000167065	ENSG00000135333
Uniprot IDs		F2Z2P2 Q8NEJ0	A0A7P0T9G1 A0A7P0T9L5 A0A7P0T9V9 A0A7P0TA58 Q15375
PDB IDs		2ESB	2REI 3DKO 3H8M 3NRU 7EEC 7EED 7EEF
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Kinase Activity ATP Binding Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of MAPK Cascade Ephrin Receptor Activity Transferase Activity Signal Transduction Positive Regulation Of MAPK Cascade Growth Factor Binding Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Coreceptor Activity Transmembrane-ephrin Receptor Activity Basal Plasma Membrane Regulation Of Intracellular Signal Transduction Plasma Membrane Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Organization Neuron Projection Guidance Axon Guidance ERBB3:ERBB2 Complex Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of Signal Transduction Heart Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuregulin Receptor Activity Insulin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Bounded Cell Projection Organization Insulin Receptor Complex Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Insulin Binding System Development	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Side Of Membrane Neuron Projection Guidance Axon Guidance Protein Serine/threonine Phosphatase Activity Transmembrane-ephrin Receptor Activity Protein Tyrosine/serine/threonine Phosphatase Activity Positive Regulation Of Amyloid Precursor Protein Catabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell-cell Signaling Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Pseudophosphatase Activity Phosphatase Activity Protein Dephosphorylation Regulation Of Cell Adhesion Notochord Formation F-box Domain Binding Protein Tyrosine Phosphatase Activity Plasma Membrane Bounded Cell Projection Organization Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Oxygen-glucose Deprivation
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