DUSP18 and ROR1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP18	ROR1
Description		dual specificity phosphatase 18	receptor tyrosine kinase like orphan receptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Membrane	Stress Fiber Cytoplasm Plasma Membrane Cell Surface Membrane Axon Cell Projection Receptor Complex Axon Terminus
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Signaling Receptor Activity Wnt Receptor Activity
	Biological Process	Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Sensory Perception Of Sound Cell Population Proliferation Astrocyte Development Wnt Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Inner Ear Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 IGF1R INSR MAPK8IP2 PTK7 ROR1 ROR2 TEK	14 interacting genes: APP DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 ILKAP MFHAS1 PPM1B PPM1F PTN PTPN6 PTPRR STYX
Entrez ID		150290	4919
HPRD ID		13253	03821
Ensembl ID		ENSG00000167065	ENSG00000185483
Uniprot IDs		F2Z2P2 Q8NEJ0	Q01973
PDB IDs		2ESB	5Z55 6BA5 6BAN 6TU9 7TNG
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Kinase Activity ATP Binding Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of MAPK Cascade Ephrin Receptor Activity Transferase Activity Signal Transduction Positive Regulation Of MAPK Cascade Growth Factor Binding Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Coreceptor Activity Transmembrane-ephrin Receptor Activity Basal Plasma Membrane Regulation Of Intracellular Signal Transduction Plasma Membrane Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Organization Neuron Projection Guidance Axon Guidance ERBB3:ERBB2 Complex Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of Signal Transduction Heart Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuregulin Receptor Activity Insulin Receptor Activity Regulation Of ERK1 And ERK2 Cascade Plasma Membrane Bounded Cell Projection Organization Insulin Receptor Complex Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Insulin Binding System Development	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Dephosphorylation Protein Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Regulation Of Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Regulation Of Epithelial Cell Migration Peptidyl-threonine Dephosphorylation Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Response To Auditory Stimulus Negative Regulation Of Cell Communication Myeloid Leukocyte Activation Molecular Function Activator Activity Regulation Of JNK Cascade Positive Regulation Of Chemotaxis Neuron Projection Regeneration Regulation Of Signal Transduction Microglial Cell Activation Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Long-term Synaptic Potentiation Response To Mechanical Stimulus Dendrite Development Phosphate-containing Compound Metabolic Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Protein Localization
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