NCAN and TNC

Number of citations: 0 (PubMedID 9341124)
Data Source: BioGRID (far western blotting), HPRD (in vivo)

		NCAN	TNC
Name		neurocan	tenascin C
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Lysosomal Lumen Synapse Perineuronal Net	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Focal Adhesion Membrane Extracellular Matrix Tenascin Complex Extracellular Matrix Of Synaptic Cleft Perisynaptic Extracellular Matrix Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Syndecan Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	Regulation Of Cell Growth Osteoblast Differentiation Morphogenesis Of An Epithelium Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Population Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Regulation Of Cell Adhesion Regulation Of Cell Migration Neuron Projection Development Odontogenesis Of Dentin-containing Tooth Response To Ethanol Regulation Of Inflammatory Response Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1	Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Beta-D-Glucose Thiodigalactoside Hyaluronic acid	None
GWAS		Bipolar disorder ( 33263727 31043756 21353194 24618891 ) Bipolar I disorder ( 31043756 ) Bipolar II disorder ( 31043756 ) Brain morphology (MOSTest) ( 32665545 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Cholesterol, total ( 19060911 26780889 ) LDL cholesterol ( 26780889 18193043 19060911 19060906 ) Nonalcoholic fatty liver disease ( 29385134 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 23974872 29483656 ) Triglycerides ( 19060911 19060906 18193043 )	Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Developmental language disorder (syntactic complexity) ( 27016271 ) Inflammatory bowel disease ( 23128233 ) Metabolite levels ( 23823483 ) Mosquito bite size ( 28199695 ) Osteoarthritis (hip) ( 30374069 ) Response to bupropion and depression ( 27622933 )
Novel Interactors		5 novel interactors: CCDC9 GDF1 ZNF121 ZNF66 ZNF99	5 novel interactors: ASTN2 ITGB1 POLE3 RAB14 TRIM32
Interacting Genes		8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR	11 interacting genes: ANXA2 CNTN1 EGFR FN1 ITGA5 MBD1 NCAN PTPRB SMOC1 SMOC2 SPARC
Entrez ID		1463	3371
HPRD ID		02897	01756
Ensembl ID		ENSG00000130287	ENSG00000041982
Uniprot IDs		O14594	B4E1W8 J3QSU6 P24821
PDB IDs		Not available	1TEN 2RB8 2RBL 5R5T 5R5U 5R5V 5R5W 5R5X 5R5Y 5R5Z 5R60 5R61 5R62 5R63 6BRB 6QNV 8FN8 8FNB
GO Terms Enriched among Interactors		Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Neuron Projection Regeneration Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Tenascin Complex Regulation Of Response To Wounding Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Adhesion Cell Migration Synapse Organization Cell Motility Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Neuron Projection Regulation Of Cell Projection Organization Regeneration Regulation Of Axonogenesis Integrin Binding Extracellular Matrix Learning Cell Junction Organization Cell-cell Adhesion Regulation Of Synaptic Plasticity Telencephalon Cell Migration Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cellular Response To Stress Forebrain Cell Migration Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Perisynaptic Extracellular Matrix Nervous System Development Chondroitin Sulfate Proteoglycan Binding Establishment Of Protein Localization To Juxtaparanode Region Of Axon Axon Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Development Learning Or Memory Regulation Of Glial Cell Differentiation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Extracellular Matrix Of Synaptic Cleft Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development	Basement Membrane Calcium Ion Binding Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Locomotion Response To Activity Integrin Alpha5-beta1 Complex Regulation Of Developmental Process Cell-matrix Adhesion Response To Muscle Activity Extracellular Matrix Binding Cell-cell Adhesion Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Calcium-independent Cell-matrix Adhesion Angiogenesis Cell-substrate Adhesion Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion CD40 Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Virus Receptor Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Fibroblast Proliferation Wound Healing, Spreading Of Epidermal Cells Ruffle Membrane Cell Migration Integrin-mediated Signaling Pathway Protease Binding Negative Regulation Of Anoikis Symbiont Entry Into Host Cell Extracellular Space Regulation Of Angiogenesis Regulation Of Vasculature Development Nuclear Matrix Cell Surface Developmental Process Cell Motility Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Anoikis Integrin Complex Regulation Of Neurogenesis Positive Regulation Of Vacuole Organization