NCAN and PTN

Number of citations of the paper that reports this interaction (PMID 9507007)
12

Data Source:
HPRD (in vitro)

		NCAN	PTN
Gene Name		neurocan	pleiotrophin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Lysosomal Lumen	Extracellular Space Endoplasmic Reticulum
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	Protein Phosphatase Inhibitor Activity Growth Factor Activity Heparin Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Axon Guidance Central Nervous System Development Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process Regulation Of Synapse Structural Plasticity	Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Learning Positive Regulation Of Cell Proliferation Bone Mineralization Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Division
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism L1CAM interactions Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis NCAM signaling for neurite out-growth Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism NCAM1 interactions Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Bipolar disorder ( 21353194) Cholesterol, total ( 19060911) LDL cholesterol ( 18193043 19060906 19060911) Triglycerides ( 18193043 19060906 19060911)
Protein-Protein Interactions		7 interactors: CNTN2 HMGB1 L1CAM NCAM1 PTN TNC TNR	97 interactors: ACTB ALK APOBEC3G ARIH2 ARL15 ATP5C1 ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CCDC53 CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DFNA5 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GNB2L1 GPD1 GPRASP2 GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RBM23 RIT1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WFDC2
Entrez ID		1463	5764
HPRD ID		02897	01199
Ensembl ID		ENSG00000130287	ENSG00000105894
Uniprot IDs		O14594 Q4LE67	P21246
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Neuron Development Neuron Differentiation Nervous System Development Cell Projection Organization Axon Development Chemotaxis Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance System Development Cell Adhesion Learning Locomotion Axonogenesis Cell Morphogenesis Involved In Neuron Differentiation Multicellular Organismal Development Anatomical Structure Development Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Developmental Process Learning Or Memory Cell Migration Cell Projection Morphogenesis Cell Differentiation Cell Part Morphogenesis Cognition Cell Motility Cell Morphogenesis Anatomical Structure Morphogenesis Single-organism Behavior Negative Regulation Of Axon Extension Involved In Regeneration Establishment Of Protein Localization To Juxtaparanode Region Of Axon Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of Apoptotic Cell Clearance Telencephalon Cell Migration Forebrain Cell Migration Behavior Organ Development Interferon-gamma-mediated Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Response To Stimulus Response To Ethanol	Cell Cycle Nitrogen Compound Metabolic Process Apoptotic Process Central Nervous System Development Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Cell Death Regulation Of Cell Cycle Death Regulation Of Protein Catabolic Process Negative Regulation Of Transferase Activity Response To Endoplasmic Reticulum Stress Regulation Of Cell Death Regulation Of Cellular Process Signal Transduction By P53 Class Mediator Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of Transferase Activity Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Brain Development Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Modification Process Viral Process Developmental Process Head Development Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Process Heterocycle Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Signaling Cellular Response To Stress Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	04fmolt4 04mg 09mg 28ng 32ng 37g 58vo2ml 64g 71ng 94ng 99mg backgrounds bat carioca chf corticosterone ctrl d2 depot endocrine epididymal freezing glycemia impair kg0 retroperitoneal t4 triglycerides weights
Tagcloud (Difference) ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	04fmolt4 04mg 09mg 28ng 32ng 37g 58vo2ml 64g 71ng 94ng 99mg backgrounds bat carioca chf corticosterone ctrl d2 depot endocrine epididymal freezing glycemia impair kg0 retroperitoneal t4 triglycerides weights
Tagcloud (Intersection) ?