NCAN and GDF1

		NCAN	GDF1
Description		neurocan	growth differentiation factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Lysosomal Lumen Synapse Perineuronal Net	Extracellular Region Extracellular Space
	Molecular Function	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	Cytokine Activity Growth Factor Activity
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	In Utero Embryonic Development Signal Transduction Endoderm Development Mesoderm Development BMP Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1	Signaling by NODAL
Drugs		Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases			Tetralogy of Fallot Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome
GWAS		Bipolar disorder ( 33263727 31043756 21353194 24618891) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 26780889 18193043 19060911 19060906) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 23974872 29483656) Triglycerides ( 19060911 19060906 18193043)
Interacting Genes		8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR	1 interacting genes: HTR4
Entrez ID		1463	2657
HPRD ID		02897	04194
Ensembl ID		ENSG00000130287	ENSG00000130283
Uniprot IDs		O14594	P27539
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Neuron Projection Regeneration Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Tenascin Complex Regulation Of Response To Wounding Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Adhesion Cell Migration Synapse Organization Cell Motility Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Neuron Projection Regulation Of Cell Projection Organization Regeneration Regulation Of Axonogenesis Integrin Binding Extracellular Matrix Learning Cell Junction Organization Cell-cell Adhesion Regulation Of Synaptic Plasticity Telencephalon Cell Migration Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cellular Response To Stress Forebrain Cell Migration Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Perisynaptic Extracellular Matrix Nervous System Development Chondroitin Sulfate Proteoglycan Binding Establishment Of Protein Localization To Juxtaparanode Region Of Axon Axon Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Development Learning Or Memory Regulation Of Glial Cell Differentiation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Extracellular Matrix Of Synaptic Cleft Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development	Large Intestinal Transit Perineuronal Net Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Serotonin Binding G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Mucus Secretion Hyaluronic Acid Binding Neurotransmitter Receptor Activity Maintenance Of Gastrointestinal Epithelium G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Appetite Epithelial Structure Maintenance Regulation Of Postsynapse Assembly G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Body Fluid Secretion Digestive System Process Lysosomal Lumen Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Golgi Lumen
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