NCAN and CNTN2

Number of citations of the paper that reports this interaction (PMID 8663515)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NCAN	CNTN2
Gene Name		neurocan	contactin 2 (axonal)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Lysosomal Lumen	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Anchored Component Of Membrane Node Of Ranvier Neuronal Cell Body Myelin Sheath Juxtaparanode Region Of Axon Synapse
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	Glycoprotein Binding Carbohydrate Binding Identical Protein Binding Protein Self-association
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Axon Guidance Central Nervous System Development Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process Regulation Of Synapse Structural Plasticity	Microtubule Cytoskeleton Organization Cell Adhesion Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Positive Regulation Of Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Myelination Regulation Of Axon Diameter Receptor Internalization Cellular Protein Localization Clustering Of Voltage-gated Potassium Channels Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Positive Regulation Of Adenosine Receptor Signaling Pathway Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism L1CAM interactions Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis NCAM signaling for neurite out-growth Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism NCAM1 interactions Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	NCAM1 interactions Axon guidance L1CAM interactions NrCAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Bipolar disorder ( 21353194) Cholesterol, total ( 19060911) LDL cholesterol ( 18193043 19060906 19060911) Triglycerides ( 18193043 19060906 19060911)
Protein-Protein Interactions		7 interactors: CNTN2 HMGB1 L1CAM NCAM1 PTN TNC TNR	16 interactors: CNTN1 CNTNAP2 CREBBP EGFR EP300 HDAC1 KAT2B L1CAM NCAN NFYB NRCAM SRF TAX1BP1 TAX1BP3 TUBG1 VAC14
Entrez ID		1463	6900
HPRD ID		02897	01826
Ensembl ID		ENSG00000130287	ENSG00000184144
Uniprot IDs		O14594 Q4LE67	A1L3A3 Q02246
PDB IDs			2OM5
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Neuron Development Neuron Differentiation Nervous System Development Cell Projection Organization Axon Development Chemotaxis Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance System Development Cell Adhesion Learning Locomotion Axonogenesis Cell Morphogenesis Involved In Neuron Differentiation Multicellular Organismal Development Anatomical Structure Development Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Developmental Process Learning Or Memory Cell Migration Cell Projection Morphogenesis Cell Differentiation Cell Part Morphogenesis Cognition Cell Motility Cell Morphogenesis Anatomical Structure Morphogenesis Single-organism Behavior Negative Regulation Of Axon Extension Involved In Regeneration Establishment Of Protein Localization To Juxtaparanode Region Of Axon Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of Apoptotic Cell Clearance Telencephalon Cell Migration Forebrain Cell Migration Behavior Organ Development Interferon-gamma-mediated Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Response To Stimulus Response To Ethanol	N-terminal Peptidyl-lysine Acetylation Notch Signaling Pathway N-terminal Protein Amino Acid Acetylation Neuron Projection Development N-terminal Protein Amino Acid Modification Viral Process Rhythmic Process Neuron Development Positive Regulation Of Gene Expression Neuron Differentiation Axon Guidance Cell Morphogenesis Involved In Differentiation Cell Projection Organization Cell Adhesion Anatomical Structure Morphogenesis Cell Development Positive Regulation Of Transcription, DNA-templated Axonogenesis Central Nervous System Development Cell Communication Axon Development Positive Regulation Of Macromolecule Biosynthetic Process Neuronal Ion Channel Clustering Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Chemotaxis Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Positive Regulation Of Cellular Biosynthetic Process Cell Morphogenesis Nervous System Development Neuron Projection Morphogenesis Regulation Of Type I Interferon Production Neurogenesis Histone Acetylation Eyelid Development In Camera-type Eye Embryo Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Regulation Of Androgen Receptor Signaling Pathway Protein Acetylation Locomotion Cell Differentiation Positive Regulation Of Metabolic Process Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Innate Immune Response Signaling Response To Stimulus
Tagcloud ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	aff2 algorithm arpp21 bioinformatics cacna2d3 degs depthfirst differentially downloaded economic enormous enrichment exonlevel gbm glioblastoma gliomas gse9385 hist1h3a hub impair od oligodendroglioma omnibus ontology ppi proteinprotein shared society splicing
Tagcloud (Difference) ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	aff2 algorithm arpp21 bioinformatics cacna2d3 degs depthfirst differentially downloaded economic enormous enrichment exonlevel gbm glioblastoma gliomas gse9385 hist1h3a hub impair od oligodendroglioma omnibus ontology ppi proteinprotein shared society splicing
Tagcloud (Intersection) ?