NCAN and TNR

Number of citations of the paper that reports this interaction (PubMedID 9507007)
0

Data Source:
BioGRID (pull down)

		NCAN	TNR
Description		neurocan	tenascin R
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Lysosomal Lumen Synapse Perineuronal Net	Extracellular Region Extracellular Space Cell Surface Extracellular Matrix Membrane Raft Perineuronal Net Tenascin Complex Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	Cell Adhesion Neuron Cell-cell Adhesion Nervous System Development Axon Guidance Associative Learning Negative Regulation Of Neuron Projection Development Telencephalon Cell Migration Negative Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Negative Regulation Of Axon Extension Synaptic Transmission, Glutamatergic Locomotory Exploration Behavior Regulation Of Cell Differentiation Axon Extension Axon Extension Involved In Regeneration Negative Regulation Of Axon Extension Involved In Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Transmission Of Nerve Impulse Long-term Synaptic Potentiation Neuroblast Migration
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1	ECM proteoglycans
Drugs		Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases
GWAS		Bipolar disorder ( 33263727 31043756 21353194 24618891) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 26780889 18193043 19060911 19060906) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 23974872 29483656) Triglycerides ( 19060911 19060906 18193043)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Attention deficit hyperactivity disorder ( 30563984) Body mass index ( 26426971) Corneal astigmatism ( 29422769) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Liver fibrosis in non-alcoholic fatty liver disease ( 31311600) Sleep (1/2-day periodicity) ( 33075057) Telomere length ( 30185882) Testosterone levels x fluid intelligence interaction ( 33407712) Tonometry ( 17903302)
Interacting Genes		8 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR	16 interacting genes: ACAN BCAN CCDC146 CNTN1 LGALS14 MAGEB4 NCAN NCK2 NFASC NTAQ1 POLR3C PSMA1 PTPRZ1 SIGLEC1 TRIM54 VCAN
Entrez ID		1463	7143
HPRD ID		02897	03589
Ensembl ID		ENSG00000130287	ENSG00000116147
Uniprot IDs		O14594	A1L306 Q92752
PDB IDs			8FN9 8FNA
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Neuron Projection Regeneration Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Tenascin Complex Regulation Of Response To Wounding Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Adhesion Cell Migration Synapse Organization Cell Motility Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Neuron Projection Regulation Of Cell Projection Organization Regeneration Regulation Of Axonogenesis Integrin Binding Extracellular Matrix Learning Cell Junction Organization Cell-cell Adhesion Regulation Of Synaptic Plasticity Telencephalon Cell Migration Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cellular Response To Stress Forebrain Cell Migration Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Perisynaptic Extracellular Matrix Nervous System Development Chondroitin Sulfate Proteoglycan Binding Establishment Of Protein Localization To Juxtaparanode Region Of Axon Axon Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Development Learning Or Memory Regulation Of Glial Cell Differentiation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Extracellular Matrix Of Synaptic Cleft Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development	Perineuronal Net Carbohydrate Binding Hyaluronic Acid Binding Central Nervous System Development Lysosomal Lumen Golgi Lumen Cell Adhesion Synapse Skeletal System Development Extracellular Matrix Structural Constituent Conferring Compression Resistance System Development Cell-cell Adhesion Mediator Activity Extracellular Matrix Clathrin-dependent Endocytosis Of Virus By Host Cell Protein-N-terminal Glutamine Amidohydrolase Activity
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