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NCAN
Gene Name
neurocan
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Proteinaceous Extracellular Matrix
Golgi Lumen
Lysosomal Lumen
Molecular Function
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Hyaluronic Acid Binding
Carbohydrate Binding
Biological Process
Skeletal System Development
Carbohydrate Metabolic Process
Cell Adhesion
Axon Guidance
Central Nervous System Development
Pathogenesis
Extracellular Matrix Organization
Glycosaminoglycan Metabolic Process
Chondroitin Sulfate Metabolic Process
Chondroitin Sulfate Biosynthetic Process
Chondroitin Sulfate Catabolic Process
Dermatan Sulfate Biosynthetic Process
Small Molecule Metabolic Process
Regulation Of Synapse Structural Plasticity
Pathways
MPS IIIB - Sanfilippo syndrome B
Diseases of glycosylation
Axon guidance
Heparan sulfate/heparin (HS-GAG) metabolism
Defective B4GALT7 causes EDS, progeroid type
MPS I - Hurler syndrome
MPS IX - Natowicz syndrome
Chondroitin sulfate/dermatan sulfate metabolism
CS/DS degradation
Defective SLC26A2 causes chondrodysplasias
Glycosaminoglycan metabolism
L1CAM interactions
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST14 causes EDS, musculocontractural type
Defective PAPSS2 causes SEMD-PA
MPS IIIA - Sanfilippo syndrome A
Myoclonic epilepsy of Lafora
ECM proteoglycans
Defective CHST6 causes MCDC1
Glycogen storage diseases
MPS IIID - Sanfilippo syndrome D
A tetrasaccharide linker sequence is required for GAG synthesis
NCAM signaling for neurite out-growth
Chondroitin sulfate biosynthesis
MPS IIIC - Sanfilippo syndrome C
Diseases associated with glycosaminoglycan metabolism
NCAM1 interactions
Mucopolysaccharidoses
Defective EXT2 causes exostoses 2
MPS II - Hunter syndrome
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
MPS IV - Morquio syndrome A
Dermatan sulfate biosynthesis
Defective CHSY1 causes TPBS
MPS IV - Morquio syndrome B
MPS VII - Sly syndrome
Metabolism of carbohydrates
MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Bipolar disorder (
21353194
)
Cholesterol, total (
19060911
)
LDL cholesterol (
18193043
19060906
19060911
)
Triglycerides (
18193043
19060906
19060911
)
Protein-protein Interactions
7 interactors:
CNTN2
HMGB1
L1CAM
NCAM1
PTN
TNC
TNR
Entrez ID
1463
HPRD ID
02897
Ensembl ID
ENSG00000130287
Uniprot IDs
O14594
Q4LE67
PDB IDs
Enriched GO Terms of Interacting Partners
?
Neuron Projection Development
Neuron Development
Neuron Differentiation
Nervous System Development
Cell Projection Organization
Axon Development
Chemotaxis
Generation Of Neurons
Neurogenesis
Cell Development
Response To External Stimulus
Extracellular Matrix Organization
Extracellular Structure Organization
Axon Guidance
System Development
Cell Adhesion
Learning
Locomotion
Axonogenesis
Cell Morphogenesis Involved In Neuron Differentiation
Multicellular Organismal Development
Anatomical Structure Development
Neuron Projection Morphogenesis
Movement Of Cell Or Subcellular Component
Cell Morphogenesis Involved In Differentiation
Developmental Process
Learning Or Memory
Cell Migration
Cell Projection Morphogenesis
Cell Differentiation
Cell Part Morphogenesis
Cognition
Cell Motility
Cell Morphogenesis
Anatomical Structure Morphogenesis
Single-organism Behavior
Negative Regulation Of Axon Extension Involved In Regeneration
Establishment Of Protein Localization To Juxtaparanode Region Of Axon
Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development
Negative Regulation Of Apoptotic Cell Clearance
Telencephalon Cell Migration
Forebrain Cell Migration
Behavior
Organ Development
Interferon-gamma-mediated Signaling Pathway
Regulation Of Cell Adhesion
Positive Regulation Of Adenosine Receptor Signaling Pathway
Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Response To Stimulus
Response To Ethanol
Tagcloud
?
alt
anthropometric
apoc3
cms
col13a1
consent
corrections
efcab4b
infiltration
iu
nafld
obtaining
parvb
patatin
pnpla3
pzp
rs2073080
rs2143571
rs2228603
rs2854117
rs343062
rs6487679
rs6591182
rs738409
samm50
sequenom
snps
transaminase
triglyceride