NCAN and HMGB1

Number of citations of the paper that reports this interaction (PMID 9507007)
12

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NCAN	HMGB1
Gene Name		neurocan	high mobility group box 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Lysosomal Lumen	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Cell Surface Transcriptional Repressor Complex
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Cytokine Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Chemoattractant Activity Poly(A) RNA Binding RAGE Receptor Binding Repressing Transcription Factor Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Axon Guidance Central Nervous System Development Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process Regulation Of Synapse Structural Plasticity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Myeloid Dendritic Cell Activation Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation DNA Recombination Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Neuron Projection Development V(D)J Recombination Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Chemotaxis DNA Ligation Involved In DNA Repair Negative Regulation Of Apoptotic Cell Clearance
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism L1CAM interactions Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis NCAM signaling for neurite out-growth Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism NCAM1 interactions Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Activation of DNA fragmentation factor Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Programmed Cell Death MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Apoptotic execution phase MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Apoptosis induced DNA fragmentation Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Bipolar disorder ( 21353194) Cholesterol, total ( 19060911) LDL cholesterol ( 18193043 19060906 19060911) Triglycerides ( 18193043 19060906 19060911)	MRI atrophy measures ( 21116278)
Protein-Protein Interactions		7 interactors: CNTN2 HMGB1 L1CAM NCAM1 PTN TNC TNR	73 interactors: AES AGER AGTRAP AR ATOH1 C14orf1 CASP3 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CUX1 DNM2 DNMT1 ERF FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HR IRF2 LRIF1 MECP2 MNT NCAN NEUROD6 NFKB1 NR3C1 PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 SIX5 SOX18 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLR2 TLR4 TP53 TP73 UNC119 ZFP36 ZNF24
Entrez ID		1463	3146
HPRD ID		02897	01228
Ensembl ID		ENSG00000130287	ENSG00000189403
Uniprot IDs		O14594 Q4LE67	P09429 Q5T7C4
PDB IDs			2LY4 2YRQ
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Neuron Development Neuron Differentiation Nervous System Development Cell Projection Organization Axon Development Chemotaxis Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance System Development Cell Adhesion Learning Locomotion Axonogenesis Cell Morphogenesis Involved In Neuron Differentiation Multicellular Organismal Development Anatomical Structure Development Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Developmental Process Learning Or Memory Cell Migration Cell Projection Morphogenesis Cell Differentiation Cell Part Morphogenesis Cognition Cell Motility Cell Morphogenesis Anatomical Structure Morphogenesis Single-organism Behavior Negative Regulation Of Axon Extension Involved In Regeneration Establishment Of Protein Localization To Juxtaparanode Region Of Axon Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Negative Regulation Of Apoptotic Cell Clearance Telencephalon Cell Migration Forebrain Cell Migration Behavior Organ Development Interferon-gamma-mediated Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Response To Stimulus Response To Ethanol	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Cellular Metabolic Process Multicellular Organismal Development Regulation Of Cellular Process System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Anterior/posterior Pattern Specification Regulation Of Cell Differentiation Pattern Specification Process
Tagcloud ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated
Tagcloud (Difference) ?		alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 samm50 sequenom snps transaminase triglyceride	1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy index mobility pbmcs rage remarkably spondylitis surface tlr2 tlr4 untreated
Tagcloud (Intersection) ?