DYNLL2 and OTUD6A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DYNLL2	OTUD6A
Description		dynein light chain LC8-type 2	OTU deubiquitinase 6A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Microtubule-based Process	Proteolysis Protein Deubiquitination Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1	19 interacting genes: CBLC CFTR DPYSL3 DYNLL1 DYNLL2 EMX2 MYCL NUP62 PDLIM7 POM121 RBCK1 RNF2 SSBP1 TRIM39 TRIM46 TRIM5 TRIM7 UBC VPS52
Entrez ID		140735	139562
HPRD ID		06489	13681
Ensembl ID		ENSG00000264364	ENSG00000189401
Uniprot IDs		Q96FJ2	Q7L8S5
PDB IDs		2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?		Microtubule Binding	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Cytoplasmic Dynein Complex Structural Constituent Of Nuclear Pore Filamentous Actin Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Stereocilium Bundle Organization Regulation Of DNA-binding Transcription Factor Activity Embryonic Ectodermal Digestive Tract Development Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex Negative Regulation Of ERBB Signaling Pathway Myosin V Complex Protein Modification Process Ciliary Tip Positive Regulation Of Anion Channel Activity Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Identical Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Axon Cytoplasm Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Anterograde Dense Core Granule Transport Omegasome Cholesterol Transport Sterol Transport Regulation Of Protein Localization Positive Regulation Of Monoatomic Anion Transport RING-like Zinc Finger Domain Binding Zinc Ion Binding Regulation Of Mitochondrial DNA Replication Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Scaffold Protein Binding Nitric-oxide Synthase Inhibitor Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway PTB Domain Binding Proximal Neuron Projection
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