DYNLL2 and SKAP1

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		DYNLL2	SKAP1
Description		dynein light chain LC8-type 2	src kinase associated phosphoprotein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding
	Biological Process	Microtubule-based Process	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Body mass index ( 25673413 28892062) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epithelial ovarian cancer ( 25581431) Food allergy ( 29030101) Generalized epilepsy ( 22949513) HDL cholesterol levels ( 32203549) Intelligence ( 28530673) Keratoconus ( 33649486) Lean body mass ( 28552196) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Ovarian cancer ( 20852632) Peanut allergy ( 29030101) Pulse pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1	13 interacting genes: APP BLCAP DYNLL2 EEIG1 FYB1 FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC
Entrez ID		140735	8631
HPRD ID		06489	05396
Ensembl ID		ENSG00000264364	ENSG00000141293
Uniprot IDs		Q96FJ2	Q86WV1 V9HW03
PDB IDs		2XQQ 3P8M 4D07 7CNU	1U5D
Enriched GO Terms of Interacting Partners?		Microtubule Binding	Ephrin Receptor Binding Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Membrane Raft T Cell Costimulation Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune System Process Signaling Receptor Binding Positive Regulation Of Cell Activation Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Signaling Receptor Activator Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of T Cell Activation Regulation Of Immune System Process Phospholipase Activator Activity Positive Regulation Of Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Scaffold Protein Binding Immune System Process Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Regulation Of T Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Defense Response Protein Tyrosine Kinase Activity CD8 Receptor Binding Growth Factor Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway
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