DYNLL2 and SMCP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DYNLL2	SMCP
Description		dynein light chain LC8-type 2	sperm mitochondria associated cysteine rich protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	Cytoplasm Mitochondrion Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	Protein Binding
	Biological Process	Microtubule-based Process	Single Fertilization Penetration Of Zona Pellucida Flagellated Sperm Motility
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1	78 interacting genes: ALPP C14orf119 CALCOCO2 CGB3 CGB5 CGB8 CTAG2 CYSRT1 DYNLL1 DYNLL2 GOLGA2 GRN GUCD1 HOXA1 IGFBP6 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2C LCE2D LCE3A LCE3B LCE4A LCE5A MACO1 MT1B MT1M NBPF19 NOTCH2NLA PCSK5 PLEKHG4 PLSCR1 PLSCR3 PPP1R27 PRDX5 RGS17 SLC39A7 SPRY1 TCF4 TRIM42 UBL5 VASN
Entrez ID		140735	4184
HPRD ID		06489	03093
Ensembl ID		ENSG00000264364	ENSG00000163206
Uniprot IDs		Q96FJ2	P49901 Q5T7P5
PDB IDs		2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?		Microtubule Binding	Intermediate Filament Keratin Filament Epidermis Development Keratinization Hair Cycle Tissue Development Identical Protein Binding Cytosol Lead Ion Binding Mercury Ion Binding Intracellular Zinc Ion Homeostasis
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